MicroRNA 200c is a microRNA that in humans is encoded by the MIR200C
gene.
[3]
Function
MicroRNAs (miRNAs) are short (20-24 nt)
non-coding RNAs that are involved in
post-transcriptional regulation of
gene expression in
multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by
RNA polymerase II as part of capped and
polyadenylatedprimary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the
Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic
Dicer ribonuclease to generate the mature miRNA and
antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a
RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Uhlmann S, Zhang JD, Schwäger A, Mannsperger H, Riazalhosseini Y, Burmester S, Ward A, Korf U, Wiemann S, Sahin O (July 2010). "miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer". Oncogene. 29 (30): 4297–306.
doi:
10.1038/onc.2010.201.
PMID20514023.
S2CID41341426.
MicroRNA 200c is a microRNA that in humans is encoded by the MIR200C
gene.
[3]
Function
MicroRNAs (miRNAs) are short (20-24 nt)
non-coding RNAs that are involved in
post-transcriptional regulation of
gene expression in
multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by
RNA polymerase II as part of capped and
polyadenylatedprimary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the
Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic
Dicer ribonuclease to generate the mature miRNA and
antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a
RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Uhlmann S, Zhang JD, Schwäger A, Mannsperger H, Riazalhosseini Y, Burmester S, Ward A, Korf U, Wiemann S, Sahin O (July 2010). "miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer". Oncogene. 29 (30): 4297–306.
doi:
10.1038/onc.2010.201.
PMID20514023.
S2CID41341426.