MHC class I polypeptide-related sequence B (MICB) is a
protein that is encoded by the MICBgene located within MHC locus.[5] MICB is related to
MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail.[5] MICB is a
stress-induced ligand for
NKG2D receptor.[6] The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.[7]
^Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (Jul 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9.
doi:
10.1126/science.285.5428.727.
PMID10426993.
Braud VM, Allan DS, McMichael AJ (Feb 1999). "Functions of nonclassical MHC and non-MHC-encoded class I molecules". Current Opinion in Immunology. 11 (1): 100–8.
doi:
10.1016/S0952-7915(99)80018-1.
PMID10047540.
Leelayuwat C, Townend DC, Degli-Esposti MA, Abraham LJ, Dawkins RL (1994). "A new polymorphic and multicopy MHC gene family related to nonmammalian class I". Immunogenetics. 40 (5): 339–51.
doi:
10.1007/BF01246675.
PMID7927538.
S2CID10504768.
Bahram S, Spies T (1996). "Nucleotide sequence of a human MHC class I MICB cDNA". Immunogenetics. 43 (4): 230–3.
doi:
10.1007/BF00587305.
PMID8575823.
Bahram S, Shiina T, Oka A, Tamiya G, Inoko H (1997). "Genomic structure of the human MHC class I MICB gene". Immunogenetics. 45 (2): 161–2.
doi:
10.1007/s002510050184.
PMID8952966.
S2CID26270690.
Gaudieri S, Leelayuwat C, Townend DC, Mullberg J, Cosman D, Dawkins RL (1997). "Allelic and interlocus comparison of the PERB11 multigene family in the MHC". Immunogenetics. 45 (3): 209–16.
doi:
10.1007/s002510050191.
PMID8995188.
S2CID6658841.
Ando H, Mizuki N, Ota M, Yamazaki M, Ohno S, Goto K, Miyata Y, Wakisaka K, Bahram S, Inoko H (1997). "Allelic variants of the human MHC class I chain-related B gene (MICB)". Immunogenetics. 46 (6): 499–508.
doi:
10.1007/s002510050311.
PMID9321430.
S2CID1912407.
Groh V, Steinle A, Bauer S, Spies T (Mar 1998). "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells". Science. 279 (5357): 1737–40.
doi:
10.1126/science.279.5357.1737.
PMID9497295.
MHC class I polypeptide-related sequence B (MICB) is a
protein that is encoded by the MICBgene located within MHC locus.[5] MICB is related to
MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail.[5] MICB is a
stress-induced ligand for
NKG2D receptor.[6] The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.[7]
^Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (Jul 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9.
doi:
10.1126/science.285.5428.727.
PMID10426993.
Braud VM, Allan DS, McMichael AJ (Feb 1999). "Functions of nonclassical MHC and non-MHC-encoded class I molecules". Current Opinion in Immunology. 11 (1): 100–8.
doi:
10.1016/S0952-7915(99)80018-1.
PMID10047540.
Leelayuwat C, Townend DC, Degli-Esposti MA, Abraham LJ, Dawkins RL (1994). "A new polymorphic and multicopy MHC gene family related to nonmammalian class I". Immunogenetics. 40 (5): 339–51.
doi:
10.1007/BF01246675.
PMID7927538.
S2CID10504768.
Bahram S, Spies T (1996). "Nucleotide sequence of a human MHC class I MICB cDNA". Immunogenetics. 43 (4): 230–3.
doi:
10.1007/BF00587305.
PMID8575823.
Bahram S, Shiina T, Oka A, Tamiya G, Inoko H (1997). "Genomic structure of the human MHC class I MICB gene". Immunogenetics. 45 (2): 161–2.
doi:
10.1007/s002510050184.
PMID8952966.
S2CID26270690.
Gaudieri S, Leelayuwat C, Townend DC, Mullberg J, Cosman D, Dawkins RL (1997). "Allelic and interlocus comparison of the PERB11 multigene family in the MHC". Immunogenetics. 45 (3): 209–16.
doi:
10.1007/s002510050191.
PMID8995188.
S2CID6658841.
Ando H, Mizuki N, Ota M, Yamazaki M, Ohno S, Goto K, Miyata Y, Wakisaka K, Bahram S, Inoko H (1997). "Allelic variants of the human MHC class I chain-related B gene (MICB)". Immunogenetics. 46 (6): 499–508.
doi:
10.1007/s002510050311.
PMID9321430.
S2CID1912407.
Groh V, Steinle A, Bauer S, Spies T (Mar 1998). "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells". Science. 279 (5357): 1737–40.
doi:
10.1126/science.279.5357.1737.
PMID9497295.