From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Major facilitator superfamily domain containing 5 is an
atypical SLC expressed in neuronal plasma membrane.
[5] It is a plausible
Solute carrier transporter.
[6] It transports
molybdate anions,
[7] and it interacts with
GLP-1R .
[8]
MFSD5 belongs to
AMTF 6.
[9]
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000182544 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000045665 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016).
"The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis" . PLOS ONE . 11 (6): e0156912.
Bibcode :
2016PLoSO..1156912P .
doi :
10.1371/journal.pone.0156912 .
PMC
4896477 .
PMID
27272503 .
^ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences . 38 (3): 305–315.
doi :
10.1016/j.tips.2016.11.008 .
PMID
27939446 .
^ Tejada-Jiménez M, Galván A, Fernández E (April 2011).
"Algae and humans share a molybdate transporter" . Proceedings of the National Academy of Sciences of the United States of America . 108 (16): 6420–6425.
Bibcode :
2011PNAS..108.6420T .
doi :
10.1073/pnas.1100700108 .
PMC
3080982 .
PMID
21464289 .
^ Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013).
"The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity" . Molecular Endocrinology . 27 (9): 1550–1563.
doi :
10.1210/me.2013-1047 .
PMC
5415235 .
PMID
23864651 .
^ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017).
"Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression" . Open Biology . 7 (9): 170142.
doi :
10.1098/rsob.170142 .
PMC
5627054 .
PMID
28878041 .