MED10

MED10
Identifiers
Aliases	MED10, NUT2, TRG20, L6, mediator complex subunit 10
External IDs	OMIM: 612382; MGI: 106331; HomoloGene: 44533; GeneCards: MED10; OMA: MED10 - orthologs
Gene location ( Human)
Chr.	Chromosome 5 (human)
End	6,378,571 bp
Gene location ( Mouse)
Chr.	Chromosome 13 (mouse)
End	69,964,223 bp
RNA expression pattern
	Top expressed in
	monocyte; ; Brodmann area 9; ; prefrontal cortex; ; oocyte; ; cingulate gyrus; ; thoracic aorta; ; ascending aorta; ; hypothalamus; ; left coronary artery; ; tibial nerve;
	Top expressed in
	seminiferous tubule; ; morula; ; facial motor nucleus; ; neural tube; ; ovary; ; medial ganglionic eminence; ; otic placode; ; yolk sac; ; secondary oocyte; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase activity; transcription coregulator activity;
Cellular component	nucleoplasm; mediator complex; ubiquitin ligase complex; nucleus; core mediator complex;
Biological process	positive regulation of transcription by RNA polymerase II; protein ubiquitination; transcription initiation from RNA polymerase II promoter; stem cell population maintenance; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; transcription, DNA-templated;
	Sources: Amigo / QuickGO
Orthologs
	84246
	28077
	ENSG00000133398
	ENSMUSG00000021598
	Q9BTT4
	Q9CXU0
	NM_032286
	NM_138596; NM_001378925
	NP_115662
	NP_613062; NP_001365854
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator complex subunit 10 (Med10) is a protein that in humans is encoded by the MED10 gene.^[5]

Function

Med10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.^[6][supplied by OMIM, Oct 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133398 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021598 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Mediator complex subunit 10".
^ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17). American Society for Biochemistry & Molecular Biology (ASBMB): 15123–7. doi: 10.1074/jbc.c300054200. PMID 12584197.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133398 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021598 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mediator complex subunit 10".

[Sato_Tomomori-Sato_Banks_Sorokina_pp._15123–15127-6] Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17). American Society for Biochemistry & Molecular Biology (ASBMB): 15123–7. doi: 10.1074/jbc.c300054200. PMID 12584197.

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