The DBL proto-oncogene is a
protein that in humans is encoded by the MCF2gene.[4][5][6]
The commonly-used name DBL is derived from “diffuse B-cell lymphoma”, the
cancer type where this gene was first identified as an
oncogene,[7] while the name MCF2 name derives from “MCF.2 cell line-derived transforming sequence”.[8]
DBL is the founding member of a large family of
guanine nucleotide exchange factors that share a common
DBL-homology (DH) domain), so DBL is also named as a member of this RhoGEF family as ARHGEF21. DH domains function to activate
small GTPases of the
Rho family by facilitating release of
GDP from an inactive Rho GTPase and binding of
GTP to activate it. In particular, DBL activates the Rho family member
Cdc42.[9]
Gene recombinations that result in the loss of N-terminal regions produce MCF2 variants with oncogenic activity.[supplied by OMIM][6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D (December 1988). "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences". Oncogene. 3 (6): 709–15.
PMID2577874.
^Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6.
doi:
10.1159/000133316.
PMID1611909.
Ron D, Zannini M, Lewis M, Wickner RB, Hunt LT, Graziani G, et al. (April 1991). "A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr". The New Biologist. 3 (4): 372–9.
PMID2065022.
Kato J, Kaziro Y, Satoh T (February 2000). "Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation". Biochemical and Biophysical Research Communications. 268 (1): 141–7.
doi:
10.1006/bbrc.2000.2106.
PMID10652228.
Palmieri G, de Franciscis V, Casamassimi A, Romano G, Torino A, Pingitore P, et al. (July 2000). "Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site". Gene. 253 (1): 107–15.
doi:
10.1016/S0378-1119(00)00212-2.
PMID10925207.
Jin S, Exton JH (November 2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochemical and Biophysical Research Communications. 277 (3): 718–21.
doi:
10.1006/bbrc.2000.3744.
PMID11062019.
Komai K, Okayama R, Kitagawa M, Yagi H, Chihara K, Shiozawa S (December 2002). "Alternative splicing variants of the human DBL (MCF-2) proto-oncogene". Biochemical and Biophysical Research Communications. 299 (3): 455–8.
doi:
10.1016/S0006-291X(02)02645-1.
hdl:20.500.14094/D2002682.
PMID12445822.
The DBL proto-oncogene is a
protein that in humans is encoded by the MCF2gene.[4][5][6]
The commonly-used name DBL is derived from “diffuse B-cell lymphoma”, the
cancer type where this gene was first identified as an
oncogene,[7] while the name MCF2 name derives from “MCF.2 cell line-derived transforming sequence”.[8]
DBL is the founding member of a large family of
guanine nucleotide exchange factors that share a common
DBL-homology (DH) domain), so DBL is also named as a member of this RhoGEF family as ARHGEF21. DH domains function to activate
small GTPases of the
Rho family by facilitating release of
GDP from an inactive Rho GTPase and binding of
GTP to activate it. In particular, DBL activates the Rho family member
Cdc42.[9]
Gene recombinations that result in the loss of N-terminal regions produce MCF2 variants with oncogenic activity.[supplied by OMIM][6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D (December 1988). "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences". Oncogene. 3 (6): 709–15.
PMID2577874.
^Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6.
doi:
10.1159/000133316.
PMID1611909.
Ron D, Zannini M, Lewis M, Wickner RB, Hunt LT, Graziani G, et al. (April 1991). "A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr". The New Biologist. 3 (4): 372–9.
PMID2065022.
Kato J, Kaziro Y, Satoh T (February 2000). "Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation". Biochemical and Biophysical Research Communications. 268 (1): 141–7.
doi:
10.1006/bbrc.2000.2106.
PMID10652228.
Palmieri G, de Franciscis V, Casamassimi A, Romano G, Torino A, Pingitore P, et al. (July 2000). "Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site". Gene. 253 (1): 107–15.
doi:
10.1016/S0378-1119(00)00212-2.
PMID10925207.
Jin S, Exton JH (November 2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochemical and Biophysical Research Communications. 277 (3): 718–21.
doi:
10.1006/bbrc.2000.3744.
PMID11062019.
Komai K, Okayama R, Kitagawa M, Yagi H, Chihara K, Shiozawa S (December 2002). "Alternative splicing variants of the human DBL (MCF-2) proto-oncogene". Biochemical and Biophysical Research Communications. 299 (3): 455–8.
doi:
10.1016/S0006-291X(02)02645-1.
hdl:20.500.14094/D2002682.
PMID12445822.