Methyl-CpG-binding domain protein 3 is a
protein that in humans is encoded by the MBD3gene.[5][6][7]
Function
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins
MECP2,
MBD1,
MBD2, MBD3, and
MBD4 comprise a family of nuclear proteins related by the presence in each of a
methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA but instead binds to
hydroxymethylated DNA.[8] The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the
NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.[7]
MBD3 also contains the
coiled‐coil domain common to all three MBD3 isoforms.[9]
Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (September 1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation". Nature Genetics. 23 (1): 62–6.
doi:
10.1038/12664.
PMID10471500.
S2CID52868103.
Schlegel J, Güneysu S, Mennel HD (2002). "Expression of the genes of methyl-binding domain proteins in human gliomas". Oncology Reports. 9 (2): 393–5.
doi:
10.3892/or.9.2.393.
PMID11836615.
Methyl-CpG-binding domain protein 3 is a
protein that in humans is encoded by the MBD3gene.[5][6][7]
Function
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins
MECP2,
MBD1,
MBD2, MBD3, and
MBD4 comprise a family of nuclear proteins related by the presence in each of a
methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA but instead binds to
hydroxymethylated DNA.[8] The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the
NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.[7]
MBD3 also contains the
coiled‐coil domain common to all three MBD3 isoforms.[9]
Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (September 1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation". Nature Genetics. 23 (1): 62–6.
doi:
10.1038/12664.
PMID10471500.
S2CID52868103.
Schlegel J, Güneysu S, Mennel HD (2002). "Expression of the genes of methyl-binding domain proteins in human gliomas". Oncology Reports. 9 (2): 393–5.
doi:
10.3892/or.9.2.393.
PMID11836615.