Melanoma-associated antigen 2 is a
protein that in humans is encoded by the MAGEA2gene.[3][4][5]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as
dyskeratosis congenita. This gene has two identical copies at different
loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[5]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (Jan 1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science. 254 (5038): 1643–7.
doi:
10.1126/science.1840703.
PMID1840703.
^Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31.
doi:
10.1006/geno.1995.9945.
PMID8575766.
Brasseur F, Rimoldi D, Liénard D, et al. (1995). "Expression of MAGE genes in primary and metastatic cutaneous melanoma". Int. J. Cancer. 63 (3): 375–80.
doi:
10.1002/ijc.2910630313.
PMID7591235.
S2CID38676798.
De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9.
doi:
10.1007/BF01246677.
PMID7927540.
S2CID11331427.
De Smet C, Lurquin C, van der Bruggen P, et al. (1994). "Sequence and expression pattern of the human MAGE2 gene". Immunogenetics. 39 (2): 121–9.
doi:
10.1007/bf00188615.
PMID8276455.
S2CID13579671.
Zakut R, Topalian SL, Kawakami Y, et al. (1993). "Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines". Cancer Res. 53 (1): 5–8.
PMID8416750.
Melanoma-associated antigen 2 is a
protein that in humans is encoded by the MAGEA2gene.[3][4][5]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as
dyskeratosis congenita. This gene has two identical copies at different
loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[5]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (Jan 1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science. 254 (5038): 1643–7.
doi:
10.1126/science.1840703.
PMID1840703.
^Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31.
doi:
10.1006/geno.1995.9945.
PMID8575766.
Brasseur F, Rimoldi D, Liénard D, et al. (1995). "Expression of MAGE genes in primary and metastatic cutaneous melanoma". Int. J. Cancer. 63 (3): 375–80.
doi:
10.1002/ijc.2910630313.
PMID7591235.
S2CID38676798.
De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9.
doi:
10.1007/BF01246677.
PMID7927540.
S2CID11331427.
De Smet C, Lurquin C, van der Bruggen P, et al. (1994). "Sequence and expression pattern of the human MAGE2 gene". Immunogenetics. 39 (2): 121–9.
doi:
10.1007/bf00188615.
PMID8276455.
S2CID13579671.
Zakut R, Topalian SL, Kawakami Y, et al. (1993). "Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines". Cancer Res. 53 (1): 5–8.
PMID8416750.