LuceyâDriscoll syndrome | |
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Other names | Transient familial neonatal hyperbilirubinemia |
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LuceyâDriscoll syndrome has an autosomal recessive pattern of inheritance. | |
Specialty | DiseasesDB = 32677 |
LuceyâDriscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism. [1] It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.
![]() | This section is empty. You can help by
adding to it. (March 2022) |
The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast feeding-associated jaundice (breast-fed infants have higher bilirubin levels than formula-fed ones).
A defect in the UGT1A1-gene, also linked to CriglerâNajjar syndrome and Gilbert's syndrome, is responsible for the congenital form of LuceyâDriscoll syndrome.
![]() | This section is empty. You can help by
adding to it. (August 2017) |
Treatment is as per neonatal jaundice, and includes phototherapy and exchange transfusions. If left untreated, Lucey-Driscoll syndrome may lead to seizures, kernicterus, and even death. [2]
Once treated, most patients will have no additional complications. [2]
LuceyâDriscoll syndrome | |
---|---|
Other names | Transient familial neonatal hyperbilirubinemia |
![]() | |
LuceyâDriscoll syndrome has an autosomal recessive pattern of inheritance. | |
Specialty | DiseasesDB = 32677 |
LuceyâDriscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism. [1] It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.
![]() | This section is empty. You can help by
adding to it. (March 2022) |
The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast feeding-associated jaundice (breast-fed infants have higher bilirubin levels than formula-fed ones).
A defect in the UGT1A1-gene, also linked to CriglerâNajjar syndrome and Gilbert's syndrome, is responsible for the congenital form of LuceyâDriscoll syndrome.
![]() | This section is empty. You can help by
adding to it. (August 2017) |
Treatment is as per neonatal jaundice, and includes phototherapy and exchange transfusions. If left untreated, Lucey-Driscoll syndrome may lead to seizures, kernicterus, and even death. [2]
Once treated, most patients will have no additional complications. [2]