From Wikipedia, the free encyclopedia
The
liver plays the major role in producing proteins that are
secreted into the blood, including major plasma proteins, factors in
hemostasis and
fibrinolysis , carrier proteins, hormones, prohormones and apolipoprotein:
All
plasma proteins except
Gamma-globulins are synthesised in the liver.
[1]
Factors in hemostasis and fibrinolysis
Stimulators of coagulation:
All factors in the coagulation cascade.
[3]
While the endothelium does produce some factor VIII, the majority of factor VIII is produced in the liver.
[4]
Inhibitors of coagulation: Inactivate an enormous variety of proteinases
Fibrinolysis: Breakdown of
fibrin clots
Inhibitors of fibrinolysis
Complement components C1-9,
complement component 3 (C3)
Albumin , carries
thyroid hormones and other hormones, particularly fat soluble ones,
fatty acids to the liver, unconjugated
bilirubin , many
drugs and
Ca2+
Ceruloplasmin , carries
copper
Transcortin , carries
cortisol ,
aldosterone and
progesterone
Haptoglobin , carries free hemoglobin released from erythrocytes
Hemopexin , carries free heme released from hemoglobin
IGF binding protein , carries
insulin-like growth factor 1
Major urinary proteins , carries
pheromones in rodents
Retinol binding protein , carries
retinol
Sex hormone-binding globulin , carries
sex hormones , specifically testosterone and estradiol
Thyroxine-binding globulin , carries the
thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3)
Transthyretin , carries the thyroid hormone thyroxine (T4)
Transferrin , carries iron ions in the
ferric form (Fe3+ )
Vitamin D-binding protein , carries
vitamin D
Angiotensinogen , when converted to
angiotensin causes vasoconstriction and release of aldosterone, in effect increasing blood pressure
General reference for the list of included substances (but not their functions):
Table 45–4 in: Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch . Elsevier/Saunders. p. 1300.
ISBN
1-4160-2328-3 .
Other: