Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid.
Pemphigoid variant | Antibody isotype | Antigen | Molecular weight ( KDa) |
---|---|---|---|
Bullous pemphigoid | IgG, IgE [1] | NC16A terminal of
BPAG2 BPAG1 |
180 230 |
Gestational pemphigoid | IgG1 | NC16A terminal of
BPAG2 BPAG1 |
180 230 |
Cicatricial pemphigoid | C-terminal of BPAG2 | 180 | |
Ocular cicatricial pemphigoid | Integrin beta-4 subunit | 200 | |
Antiepiligrin cicatricial pemphigoid [nb 1] | Laminin 5 (Epiligrin, Laminin 332) | ||
Linear IgA bullous dermatosis |
LAD1 portion of
BPAG2 Collagen type VII |
97 290/145 | |
Protein 105 pemphigoid | Protein in lower lamina lucida | 105 |
Of note, there are also several other diseases that are caused by auto-antibodies that target the same anatomic area of the skin which is termed the basement membrane zone. These diseases include:
Disease | Antibody isotype | Antigen | Molecular weight ( KDa) |
---|---|---|---|
Epidermolysis bullosa acquisita | Collagen type VII | 290/145 | |
Bullous lupus erythematosus | Collagen type VII | 290/145 | |
Lichen planus pemphigoides [nb 2] | BPAG2 | 180 |
Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid.
Pemphigoid variant | Antibody isotype | Antigen | Molecular weight ( KDa) |
---|---|---|---|
Bullous pemphigoid | IgG, IgE [1] | NC16A terminal of
BPAG2 BPAG1 |
180 230 |
Gestational pemphigoid | IgG1 | NC16A terminal of
BPAG2 BPAG1 |
180 230 |
Cicatricial pemphigoid | C-terminal of BPAG2 | 180 | |
Ocular cicatricial pemphigoid | Integrin beta-4 subunit | 200 | |
Antiepiligrin cicatricial pemphigoid [nb 1] | Laminin 5 (Epiligrin, Laminin 332) | ||
Linear IgA bullous dermatosis |
LAD1 portion of
BPAG2 Collagen type VII |
97 290/145 | |
Protein 105 pemphigoid | Protein in lower lamina lucida | 105 |
Of note, there are also several other diseases that are caused by auto-antibodies that target the same anatomic area of the skin which is termed the basement membrane zone. These diseases include:
Disease | Antibody isotype | Antigen | Molecular weight ( KDa) |
---|---|---|---|
Epidermolysis bullosa acquisita | Collagen type VII | 290/145 | |
Bullous lupus erythematosus | Collagen type VII | 290/145 | |
Lichen planus pemphigoides [nb 2] | BPAG2 | 180 |