This is a list of notable people from Tegucigalpa, capital of Honduras.

• Arturo Córdoba, runner
• Ana Galindo, swimmer
• Iizzwa Medina, table tennis player
• Bayron Molina, boxer
• Luis Alonso Morán, judoka
• Indira Murillo, journalist and basketballer
• Karen Vilorio, swimmer

• Óscar Acosta, writer and politician
• Marlene Alvarenga, politician and pastor
• Nasry Asfura, politician
• Yadira Bendaña, journalist and politician
• Rosa Elena Bonilla, politician
• Armando Calidonio, politician
• Rigoberto Chang Castillo, politician
• María Martha Díaz Velásquez, politician
• Mary Elizabeth Flores, journalist and politician
• Matías Funes, academic and politician
• Justo Herrera, politician
• María Josefa Lastiri, former first lady of the Federal Republic of Central America, Honduras, El Salvador, and Costa Rica
• Juan Fernando Lobo, television host and politician
• Francisco Morazán, Central American head of state and unionist; namesake of the city's department
• Salvador Nasralla, journalist and politician
• Mauricio Oliva, surgeon and politician
• Waldina Paz, politician
• Luis Redondo, politician
• Jorge Arturo Reina Idiáquez, politician
• Antonio Rivera Callejas, politician
• Joaquín Rivera, politician and military leader
• Erick Mauricio Rodríguez, politician
• Ramón Rosa, journalist and politician
• Elvin Santos, former vice president of Honduras
• Beatriz Valle, dentist, diplomat, politician, and television presenter
• Diego Vigil y Cocaña, last president of the Federal Republic of Central America
• Mauricio Villeda, politician
• José Rodolfo Zelaya, politician

• Marco Aurelio Soto, former president of Honduras
• Policarpo Bonilla, former president of Honduras
• José Trinidad Cabañas, former president of Honduras
• Tiburcio Carias Andino, former President of Honduras
• Xiomara Castro, current president of Honduras
• Miguel R. Dávila, former president of Honduras
• Juan Francisco de Molina, first president of Honduras
• Carlos Roberto Flores, former president of Honduras
• Juan Manuel Gálvez, former president of Honduras
• José Santos Guardiola, former president of Honduras
• Rafael Leonardo Callejas, former president of Honduras
• Juan Lindo, former president of Honduras
• Porfirio Lobo Sosa, former president of Honduras
• Rafael López Gutiérrez, former president of Honduras
• Julio Lozano Díaz, former president of Honduras

• Rosalinda Bueso, diplomat
• Fernando Palma, diplomat and actor
• Ricardo Zúñiga, American diplomat

• Oscar Acosta, writer
• Eduardo Bähr, writer and actor
• Rafael Casco, surrealist style artist
• Horacio Castellanos Moya, author
• Amanda Castro, poet
• Augusto Coello, writer
• Pompeyo del Valle, poet and journalist
• Rocsi Diaz, television and radio personality
• Édgar Flores, actor
• Carlos Gutiérrez, writer and diplomat
• Guadalupe Haertling, composer
• Low Jack, DJ
• Ana Jurka, journalist
• Isabella Lovestory, singer
• Augusto Monterroso, writer
• Leticia de Oyuela, historian
• Satcha Pretto, journalist
• Roberto Sosa, poet
• Lorena Vindel, actress
• Daniel Zacapa, actor
• José Zúñiga, actor

• Alba Alonso de Quesada, lawyer and academic
• Pablo José Cámbar, academic and physician
• Marco Tulio Medina, neurologist and scientist
• José Antonio Molina Rosito, botanist
• Salvador Moncada, pharmacologist
• Paul Carpenter Standley, American botanist
• Julissa Villanueva, forensic pathologist

• Miguel Facussé Barjum, businessman
• Miguel Estrada, attorney
• Ana García Carías, lawyer and former first lady
• Schucry Kafie, businessman
• Dante Mossi, economist
• Maya Selva, cigar maker and tobacco grower

• Óscar Rodríguez Maradiaga, cardinal
• José Trinidad Reyes, priest
• Juan de Ugarte, missionary

• Joselina García, Miss Honduras 1997
• Carmen Juares, co-ordinator of migrant workers in Barcelona.
• Robert Seldon Lady, CIA agent
• Gladys Lanza, human rights activist
• Juan Matta-Ballesteros, drug trafficker