Below is a list of notable people born in Prilep, North Macedonia or its surroundings:

• Ipče Ahmedovski, singer
• Gregory Akindynos, theologian
• Ezgjan Alioski, football player
• Metodija Andonov-Čento, first president of ASNOM and of the Socialist Republic of Macedonia
• George Atanasoski, politician and founder of several companies
• Atanas Badev, composer
• Dobrila Grasheska, singer
• Marko Cepenkov, folklorist
• Haris Hajradinović, football player
• Blaže Koneski, poet, writer, literary translator, linguistic scholar (codification of standard Macedonian)
• Prince Marko, Macedonian king
• Ilčo Naumoski, football player
• Petar Naumoski, former basketball player and current politician
• Mile Nedelkoski, writer
• Jane Nikolovski, football goalkeeper
• Dositej Novaković, Orthodox bishop
• Ali Fethi Okyar, Turkish diplomat and politician
• Elena Petreska, pop singer
• Gjorče Petrov, leader of the Internal Macedonian-Adrianople Revolutionary Organization (IMARO)
• Petar Popović, Serbian architect
• Toše Proeski, Macedonian music megastar
• Goce Sedloski, football player, defender
• Gligor Sokolović, Chetnik vojvoda
• Mihail Solunov, journalist and monk
• Vlatko Stefanovski, ethno-rock jazz fusion guitar player
• Dimitar Talev, writer
• Elena Velevska, turbo folk and popular music singer