^Data on the exact incidence of the different adverse effects is greatly lacking so only rough approximations of adverse effect incidence is available
^Refer to main text below for details on this adverse effect
^A drop in blood pressure that results from standing up
^A disturbance in the electrical cycle of the heart
^Elevated serum levels of the lactation-related hormone
prolactin. This in turn can result, in the short term, at least, in
galactorrhoea (lactation that is unrelated to pregnancy or breastfeeding),
gynaecomastia (swollen breast tissue), sexual dysfunction and
amenorrhoea (the absence of the menstrual period in women). Whereas in the long-term hyperprolactinaemia can result in
osteoporosis (brittle bones).
^An impaired ability to regulate one's body temperature
^The hypothalamus of the brain regulates the release of a number of hormones as well as a few "housekeeping" functions such as tight control over body temperature
^Glucose (sugar) in the urine due to there being too much glucose in the blood for the kidneys to reabsorb it all when filtrate goes through
loop of henle in the
nephrons of the
kidney.
^A potentially fatal collection of symptoms (i.e. syndrome) that results from an abnormally excessive release of
antidiuretic hormone (ADH). This in turn increases the reabsorption of
^A potentially fatal condition that is caused by dopamine receptor-blocking agents such as
antipsychotics. It develops over a period of days or weeks and is characterised by
rigidity,
tremor, diarrhoea,
tachycardia, altered mental status (e.g. confusion, mania, hallucinations, etc.) and
hyperthermia (high body temperature)
^An autoimmune condition in of which the body's defences attack the
neuromuscular junction – the gap between muscle and nerve cells across which the nerves send messages to the muscle cells
^An abnormally low number of
white blood cells in the blood. These cells defend the body from infections and hence this can heighten one's risk of infections
^An abnormally high number of
eosinophils – the cells of the immune system that defends the body from parasites
^An often irreversible and sometimes even fatal movement disorder characterised by involuntary, repetitive and purposeless movements of the face, extremities, lips or tongue. Usually takes a number of years to develop but in some it can appear within months or less since the initiation of antipsychotic treatment
References
^"PRODUCT INFORMATION LARGACTIL"(PDF). TGA eBusiness Services. Sanofi Aventis Pty Ltd. 28 August 2012. Retrieved 8 December 2013.
^Data on the exact incidence of the different adverse effects is greatly lacking so only rough approximations of adverse effect incidence is available
^Refer to main text below for details on this adverse effect
^A drop in blood pressure that results from standing up
^A disturbance in the electrical cycle of the heart
^Elevated serum levels of the lactation-related hormone
prolactin. This in turn can result, in the short term, at least, in
galactorrhoea (lactation that is unrelated to pregnancy or breastfeeding),
gynaecomastia (swollen breast tissue), sexual dysfunction and
amenorrhoea (the absence of the menstrual period in women). Whereas in the long-term hyperprolactinaemia can result in
osteoporosis (brittle bones).
^An impaired ability to regulate one's body temperature
^The hypothalamus of the brain regulates the release of a number of hormones as well as a few "housekeeping" functions such as tight control over body temperature
^Glucose (sugar) in the urine due to there being too much glucose in the blood for the kidneys to reabsorb it all when filtrate goes through
loop of henle in the
nephrons of the
kidney.
^A potentially fatal collection of symptoms (i.e. syndrome) that results from an abnormally excessive release of
antidiuretic hormone (ADH). This in turn increases the reabsorption of
^A potentially fatal condition that is caused by dopamine receptor-blocking agents such as
antipsychotics. It develops over a period of days or weeks and is characterised by
rigidity,
tremor, diarrhoea,
tachycardia, altered mental status (e.g. confusion, mania, hallucinations, etc.) and
hyperthermia (high body temperature)
^An autoimmune condition in of which the body's defences attack the
neuromuscular junction – the gap between muscle and nerve cells across which the nerves send messages to the muscle cells
^An abnormally low number of
white blood cells in the blood. These cells defend the body from infections and hence this can heighten one's risk of infections
^An abnormally high number of
eosinophils – the cells of the immune system that defends the body from parasites
^An often irreversible and sometimes even fatal movement disorder characterised by involuntary, repetitive and purposeless movements of the face, extremities, lips or tongue. Usually takes a number of years to develop but in some it can appear within months or less since the initiation of antipsychotic treatment
References
^"PRODUCT INFORMATION LARGACTIL"(PDF). TGA eBusiness Services. Sanofi Aventis Pty Ltd. 28 August 2012. Retrieved 8 December 2013.