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abcThe Cardinals were led by head coach Bobby Petrino until he was fired on November 11 after starting the season 2–8.
Lorenzo Ward was the interim head coach for the remainder of the season.
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abDeion Branch served as interim head coach for Louisville's appearance in the 2022 Fenway Bowl, following the departure of Scott Satterfield at the end of the regular season to accept a different position.
^
abcThe Cardinals were led by head coach Bobby Petrino until he was fired on November 11 after starting the season 2–8.
Lorenzo Ward was the interim head coach for the remainder of the season.
^
abDeion Branch served as interim head coach for Louisville's appearance in the 2022 Fenway Bowl, following the departure of Scott Satterfield at the end of the regular season to accept a different position.