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verification. (December 2009) |
The Lee–Boot effect is a phenomenon concerning the suppression or prolongation of oestrous cycles of mature female mice (and other rodents), when females are housed in groups and isolated from males. [1] [2] It is caused by the effects of an estrogen-dependent pheromone, possibly 2,5-dimethylpyrazine, [3] which is released via the urine and acts on the vomeronasal organ of recipients. [4] [5] This pheromone lowers the concentration of luteinizing hormone and elevates prolactin levels, synchronising or stopping the recipient's cycle. [6] This effect goes some way to explain why spontaneous pseudopregnancy can occur in mice. The same response is invoked from isolated females when brought into contact with urine-soaked bedding from other females' cages. The adrenal glands are required for production of the urine pheromone which is responsible for this effect. [3]
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cite journal}}
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This article needs additional citations for
verification. (December 2009) |
The Lee–Boot effect is a phenomenon concerning the suppression or prolongation of oestrous cycles of mature female mice (and other rodents), when females are housed in groups and isolated from males. [1] [2] It is caused by the effects of an estrogen-dependent pheromone, possibly 2,5-dimethylpyrazine, [3] which is released via the urine and acts on the vomeronasal organ of recipients. [4] [5] This pheromone lowers the concentration of luteinizing hormone and elevates prolactin levels, synchronising or stopping the recipient's cycle. [6] This effect goes some way to explain why spontaneous pseudopregnancy can occur in mice. The same response is invoked from isolated females when brought into contact with urine-soaked bedding from other females' cages. The adrenal glands are required for production of the urine pheromone which is responsible for this effect. [3]
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)