From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Layilin is a
protein that in humans is encoded by the LAYN
gene.
[5]
A study has shown that Layilin is upregulated in tumor infiltrating CD8+
Cytotoxic T cells of patients with
liver cancer.
[6]
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000204381 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000060594 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Entrez Gene: Layilin".
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^ Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y, Guo X, Kang B, Hu R, Huang JY, Zhang Q, Liu Z, Dong M, Hu X, Ouyang W, Peng J, Zhang Z (2017).
"Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing". Cell. 169 (7): 1342–1356.e16.
doi:
10.1016/j.cell.2017.05.035.
PMID
28622514.
- Bono P, Rubin K, Higgins JM, Hynes RO (2001).
"Layilin, a novel integral membrane protein, is a hyaluronan receptor". Mol. Biol. Cell. 12 (4): 891–900.
doi:
10.1091/mbc.12.4.891.
PMC
32274.
PMID
11294894.
- Borowsky ML, Hynes RO (1998).
"Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles". J. Cell Biol. 143 (2): 429–42.
doi:
10.1083/jcb.143.2.429.
PMC
2132847.
PMID
9786953.
- Forteza RM, Casalino-Matsuda SM, Falcon NS, Valencia Gattas M, Monzon ME (2012).
"Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin". J. Biol. Chem. 287 (50): 42288–98.
doi:
10.1074/jbc.M112.387795.
PMC
3516772.
PMID
23048036.
- Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO (2005). "Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin". Exp. Cell Res. 308 (1): 177–87.
doi:
10.1016/j.yexcr.2005.04.017.
PMID
15913605.