Protein kinase LYK5, also known as LYK5 or STRADα, is a human
protein and also denotes the
gene encoding it.[5][6]
Function
Endogenous
LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in
phosphorylation of both partners. Removal of endogenous LYK5 by
small interfering RNA abrogates LKB1-induced
G1 phase arrest.[6] STRADα stabilizes
LKB1 protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with
LKB1. STRADα is highly spliced in vivo,[7] and this is both developmentally regulated and tissue-specific, but the unique functions of the splice variants are not yet understood.[8]
Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312–9.
doi:
10.1016/j.tcb.2004.04.001.
PMID15183188.
Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4.
PMID12747765.
Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM (2004). "Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor". Nat. Struct. Mol. Biol. 11 (2): 193–200.
doi:
10.1038/nsmb716.
PMID14730349.
S2CID18401688.
Protein kinase LYK5, also known as LYK5 or STRADα, is a human
protein and also denotes the
gene encoding it.[5][6]
Function
Endogenous
LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in
phosphorylation of both partners. Removal of endogenous LYK5 by
small interfering RNA abrogates LKB1-induced
G1 phase arrest.[6] STRADα stabilizes
LKB1 protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with
LKB1. STRADα is highly spliced in vivo,[7] and this is both developmentally regulated and tissue-specific, but the unique functions of the splice variants are not yet understood.[8]
Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312–9.
doi:
10.1016/j.tcb.2004.04.001.
PMID15183188.
Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4.
PMID12747765.
Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM (2004). "Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor". Nat. Struct. Mol. Biol. 11 (2): 193–200.
doi:
10.1038/nsmb716.
PMID14730349.
S2CID18401688.