LRRTM1 is the first gene linked to increased odds of being
left-handed, when inherited from the father's side.[9] Possessing one particular variant of the LRRTM1 gene slightly raises the risk of
psychoticmental illnesses such as
schizophrenia, again only if inherited from the father's side.[9] As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations,[10] indicating that the gene may have shared effects on neurodevelopment in both healthy and unhealthy individuals and individuals with schizophrenia.
LRRTM1 is also critically involved in synapse formation within the dorsal
lateral geniculate nucleus (dLGN) of mice. LRRTM1 aids in the assembly of complex retinogenciulate synapses in mice, which are believed to help process complex visual signals. Lack of this gene shows decreased performance in complex visual tasks.[11]
Crow TJ, Close JP, Dagnall AM, Priddle TH (January 2009). "Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007)". Laterality. 14 (1): 3–10.
doi:
10.1080/13576500802574984.
PMID19125366.
S2CID770656.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
LRRTM1 is the first gene linked to increased odds of being
left-handed, when inherited from the father's side.[9] Possessing one particular variant of the LRRTM1 gene slightly raises the risk of
psychoticmental illnesses such as
schizophrenia, again only if inherited from the father's side.[9] As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations,[10] indicating that the gene may have shared effects on neurodevelopment in both healthy and unhealthy individuals and individuals with schizophrenia.
LRRTM1 is also critically involved in synapse formation within the dorsal
lateral geniculate nucleus (dLGN) of mice. LRRTM1 aids in the assembly of complex retinogenciulate synapses in mice, which are believed to help process complex visual signals. Lack of this gene shows decreased performance in complex visual tasks.[11]
Crow TJ, Close JP, Dagnall AM, Priddle TH (January 2009). "Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007)". Laterality. 14 (1): 3–10.
doi:
10.1080/13576500802574984.
PMID19125366.
S2CID770656.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.