LIM zinc finger domain containing 2 is a protein that in humans is encoded by the LIMS2 gene. [5]
This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
LIMS2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | LIMS2, PINCH-2, PINCH2, LGMD2W, LIM zinc finger domain containing 2, MDRCMTT | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 607908; MGI: 2385067; HomoloGene: 41214; GeneCards: LIMS2; OMA: LIMS2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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LIM zinc finger domain containing 2 is a protein that in humans is encoded by the LIMS2 gene. [5]
This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
This article incorporates text from the United States National Library of Medicine, which is in the public domain.