Pacer (also known as Rubicon-like) is a
protein that in humans is encoded by the RUBCNL
gene.[5] Pacer has been shown to increase cellular
autophagy through regulation of
PI3KC3.[6]
Pacer contains a
Rubicon homology (RH) domain at its C-terminus, which mediates binding to
small GTPase Rab7 when Rab7 is phosphorylated following mitochondrial damage[7].[8][9] This domain is shared with RH domain containing family members
Rubicon and
PLEKHM1.[10] Whereas Pacer appears to upregulate autophagic activity, Rubicon is a negative regulator of
autophagy.[10]
Pacer (also known as Rubicon-like) is a
protein that in humans is encoded by the RUBCNL
gene.[5] Pacer has been shown to increase cellular
autophagy through regulation of
PI3KC3.[6]
Pacer contains a
Rubicon homology (RH) domain at its C-terminus, which mediates binding to
small GTPase Rab7 when Rab7 is phosphorylated following mitochondrial damage[7].[8][9] This domain is shared with RH domain containing family members
Rubicon and
PLEKHM1.[10] Whereas Pacer appears to upregulate autophagic activity, Rubicon is a negative regulator of
autophagy.[10]