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Names | |
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IUPAC name
3-Ethoxy-1,1-dihydroxy-2-butanone
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Other names
3-Ethoxy-2-oxobutyraldehyde hydrate
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Identifiers | |
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3D model (
JSmol)
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ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.215.334 |
KEGG | |
MeSH | C005135 |
PubChem
CID
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UNII |
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CompTox Dashboard (
EPA)
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Properties | |
C6H12O4 | |
Molar mass | 148.158 g·mol−1 |
Appearance | Pale yellow syrup [1] |
Boiling point | 145 °C (293 °F; 418 K) [1] [2] |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Kethoxal (3-ethoxy-1,1-dihydroxy-2-butanone) is an organic compound that has antiviral and anaplasmosis properties. [1] [3] It also forms a stable covalent adduct with guanine, which makes it useful for nucleic acid structure determination. [4]
Kethoxal, as with other 1,2-di carbonyl compounds, [5] reacts with nucleic acids. It has high specificity for guanine over other ribonucleotides. In whole RNA, it reacts preferentially with guanine residues that are not involved in hydrogen-bonding. [6] [7] It can thus be used to probe the interactions involved with the secondary structure and other binding interactions of RNA [8] and help with nucleic acid sequence analysis. The binding is reversible, which allows the kethoxal to be removed and the original RNA recovered.[ citation needed]
![]() | |
Names | |
---|---|
IUPAC name
3-Ethoxy-1,1-dihydroxy-2-butanone
| |
Other names
3-Ethoxy-2-oxobutyraldehyde hydrate
| |
Identifiers | |
| |
3D model (
JSmol)
|
|
ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.215.334 |
KEGG | |
MeSH | C005135 |
PubChem
CID
|
|
UNII |
|
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C6H12O4 | |
Molar mass | 148.158 g·mol−1 |
Appearance | Pale yellow syrup [1] |
Boiling point | 145 °C (293 °F; 418 K) [1] [2] |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Kethoxal (3-ethoxy-1,1-dihydroxy-2-butanone) is an organic compound that has antiviral and anaplasmosis properties. [1] [3] It also forms a stable covalent adduct with guanine, which makes it useful for nucleic acid structure determination. [4]
Kethoxal, as with other 1,2-di carbonyl compounds, [5] reacts with nucleic acids. It has high specificity for guanine over other ribonucleotides. In whole RNA, it reacts preferentially with guanine residues that are not involved in hydrogen-bonding. [6] [7] It can thus be used to probe the interactions involved with the secondary structure and other binding interactions of RNA [8] and help with nucleic acid sequence analysis. The binding is reversible, which allows the kethoxal to be removed and the original RNA recovered.[ citation needed]