(Redirected from
KIF3A (gene))
Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene. [5] [6]
Function
KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. [7] This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein ( KAP3), and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intraflagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips. [8] This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry. [9]
Interactions
KIF3A has been shown to interact with MAP3K10. [10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000131437 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018395 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B (November 1999). "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina". Exp. Eye Res. 69 (5): 491–503. doi: 10.1006/exer.1999.0724. PMID 10548469.
- ^ "Entrez Gene: KIF3A kinesin family member 3A".
- ^ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70. Bibcode: 1993Natur.366..268C. doi: 10.1038/366268a0. PMID 8232586. S2CID 4367715.
- ^ Rosenbaum JL, Witman GB (November 2002). "Intraflagellar transport". Nat. Rev. Mol. Cell Biol. 3 (11): 813–25. doi: 10.1038/nrm952. PMID 12415299. S2CID 12130216.
- ^ Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N (December 1998). "Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein". Cell. 95 (6): 829–37. doi: 10.1016/S0092-8674(00)81705-5. PMID 9865700. S2CID 62805329.
- ^ Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi: 10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
Further reading
- Aizawa H, Sekine Y, Takemura R, et al. (1992). "Kinesin family in murine central nervous system". J. Cell Biol. 119 (5): 1287–96. doi: 10.1083/jcb.119.5.1287. PMC 2289715. PMID 1447303.
- Yamazaki H, Nakata T, Okada Y, Hirokawa N (1995). "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport". J. Cell Biol. 130 (6): 1387–99. doi: 10.1083/jcb.130.6.1387. PMC 2120571. PMID 7559760.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791. PMID 8889548.
- Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi: 10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
- Yang Z, Goldstein LS (1998). "Characterization of the KIF3C neural kinesin-like motor from mouse". Mol. Biol. Cell. 9 (2): 249–61. doi: 10.1091/mbc.9.2.249. PMC 25248. PMID 9450952.
- Shimizu K, Shirataki H, Honda T, et al. (1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". J. Biol. Chem. 273 (12): 6591–4. doi: 10.1074/jbc.273.12.6591. PMID 9506951.
- Hasegawa T, Yagi A, Isobe K (2000). "Interaction between GADD34 and kinesin superfamily, KIF3A". Biochem. Biophys. Res. Commun. 267 (2): 593–6. doi: 10.1006/bbrc.1999.1991. PMID 10631107.
- Jimbo T, Kawasaki Y, Koyama R, et al. (2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily". Nat. Cell Biol. 4 (4): 323–7. doi: 10.1038/ncb779. PMID 11912492. S2CID 10745049.
- Aronov S, Aranda G, Behar L, Ginzburg I (2003). "Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules". J. Cell Sci. 115 (Pt 19): 3817–27. doi: 10.1242/jcs.00058. PMID 12235292.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi: 10.1021/bi034575v. PMID 14690447.
- Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode: 2004Natur.431..268S. doi: 10.1038/nature02919. PMID 15372022.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Brown CL, Maier KC, Stauber T, et al. (2006). "Kinesin-2 is a motor for late endosomes and lysosomes". Traffic. 6 (12): 1114–24. doi: 10.1111/j.1600-0854.2005.00347.x. PMID 16262723. S2CID 25560378.
- Haraguchi K, Hayashi T, Jimbo T, et al. (2006). "Role of the kinesin-2 family protein, KIF3, during mitosis". J. Biol. Chem. 281 (7): 4094–9. doi: 10.1074/jbc.M507028200. PMID 16298999.
- Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi: 10.1038/sj.mp.4001880. PMID 17043677.
- Pantelidou M, Zographos SE, Lederer CW, et al. (2007). "Differential expression of molecular motors in the motor cortex of sporadic ALS". Neurobiol. Dis. 26 (3): 577–89. doi: 10.1016/j.nbd.2007.02.005. PMID 17418584. S2CID 2838469.
 | This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it. |
(Redirected from
KIF3A (gene))
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| Aliases | KIF3A, FLA10, KLP-20, kinesin family member 3A | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604683; MGI: 107689; HomoloGene: 38266; GeneCards: KIF3A; OMA: KIF3A - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene. [5] [6]
Function
KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. [7] This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein ( KAP3), and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intraflagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips. [8] This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry. [9]
Interactions
KIF3A has been shown to interact with MAP3K10. [10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000131437 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018395 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B (November 1999). "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina". Exp. Eye Res. 69 (5): 491–503. doi: 10.1006/exer.1999.0724. PMID 10548469.
- ^ "Entrez Gene: KIF3A kinesin family member 3A".
- ^ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70. Bibcode: 1993Natur.366..268C. doi: 10.1038/366268a0. PMID 8232586. S2CID 4367715.
- ^ Rosenbaum JL, Witman GB (November 2002). "Intraflagellar transport". Nat. Rev. Mol. Cell Biol. 3 (11): 813–25. doi: 10.1038/nrm952. PMID 12415299. S2CID 12130216.
- ^ Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N (December 1998). "Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein". Cell. 95 (6): 829–37. doi: 10.1016/S0092-8674(00)81705-5. PMID 9865700. S2CID 62805329.
- ^ Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi: 10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
Further reading
- Aizawa H, Sekine Y, Takemura R, et al. (1992). "Kinesin family in murine central nervous system". J. Cell Biol. 119 (5): 1287–96. doi: 10.1083/jcb.119.5.1287. PMC 2289715. PMID 1447303.
- Yamazaki H, Nakata T, Okada Y, Hirokawa N (1995). "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport". J. Cell Biol. 130 (6): 1387–99. doi: 10.1083/jcb.130.6.1387. PMC 2120571. PMID 7559760.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791. PMID 8889548.
- Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi: 10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
- Yang Z, Goldstein LS (1998). "Characterization of the KIF3C neural kinesin-like motor from mouse". Mol. Biol. Cell. 9 (2): 249–61. doi: 10.1091/mbc.9.2.249. PMC 25248. PMID 9450952.
- Shimizu K, Shirataki H, Honda T, et al. (1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". J. Biol. Chem. 273 (12): 6591–4. doi: 10.1074/jbc.273.12.6591. PMID 9506951.
- Hasegawa T, Yagi A, Isobe K (2000). "Interaction between GADD34 and kinesin superfamily, KIF3A". Biochem. Biophys. Res. Commun. 267 (2): 593–6. doi: 10.1006/bbrc.1999.1991. PMID 10631107.
- Jimbo T, Kawasaki Y, Koyama R, et al. (2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily". Nat. Cell Biol. 4 (4): 323–7. doi: 10.1038/ncb779. PMID 11912492. S2CID 10745049.
- Aronov S, Aranda G, Behar L, Ginzburg I (2003). "Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules". J. Cell Sci. 115 (Pt 19): 3817–27. doi: 10.1242/jcs.00058. PMID 12235292.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi: 10.1021/bi034575v. PMID 14690447.
- Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode: 2004Natur.431..268S. doi: 10.1038/nature02919. PMID 15372022.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Brown CL, Maier KC, Stauber T, et al. (2006). "Kinesin-2 is a motor for late endosomes and lysosomes". Traffic. 6 (12): 1114–24. doi: 10.1111/j.1600-0854.2005.00347.x. PMID 16262723. S2CID 25560378.
- Haraguchi K, Hayashi T, Jimbo T, et al. (2006). "Role of the kinesin-2 family protein, KIF3, during mitosis". J. Biol. Chem. 281 (7): 4094–9. doi: 10.1074/jbc.M507028200. PMID 16298999.
- Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi: 10.1038/sj.mp.4001880. PMID 17043677.
- Pantelidou M, Zographos SE, Lederer CW, et al. (2007). "Differential expression of molecular motors in the motor cortex of sporadic ALS". Neurobiol. Dis. 26 (3): 577–89. doi: 10.1016/j.nbd.2007.02.005. PMID 17418584. S2CID 2838469.
|
| This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it. |