(Redirected from
KIF18A (gene))
Kinesin family member KIF18A is a human protein encoded by the KIF18A gene. [5] [6] It is part of the kinesin family of motor proteins.
Function
KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase. [7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000121621 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027115 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi: 10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- ^ "Entrez Gene: KIF18A kinesin family member 18A".
- ^ Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G, Mayer TU (March 2007). "The Human Kinesin Kif18A Is a Motile Microtubule Depolymerase Essential for Chromosome Congression". Current Biology. 17 (6): 488–498. Bibcode: 2007CBio...17..488M. doi: 10.1016/j.cub.2007.02.036. ISSN 0960-9822. PMID 17346968.
Further reading
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi: 10.1101/gr.143000. PMC 310948. PMID 11076863.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi: 10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi: 10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi: 10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Luboshits G, Benayahu D (2005). "MS-KIF18A, new kinesin; structure and cellular expression". Gene. 351: 19–28. doi: 10.1016/j.gene.2005.02.009. PMID 15878648.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi: 10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi: 10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode: 2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Kinesin-like protein KIF18A
 | This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it. |
(Redirected from
KIF18A (gene))
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| Aliases | KIF18A, MS-PPP1R99, kinesin family member 18A | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611271; MGI: 2446977; HomoloGene: 41820; GeneCards: KIF18A; OMA: KIF18A - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Kinesin family member KIF18A is a human protein encoded by the KIF18A gene. [5] [6] It is part of the kinesin family of motor proteins.
Function
KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase. [7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000121621 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027115 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi: 10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- ^ "Entrez Gene: KIF18A kinesin family member 18A".
- ^ Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G, Mayer TU (March 2007). "The Human Kinesin Kif18A Is a Motile Microtubule Depolymerase Essential for Chromosome Congression". Current Biology. 17 (6): 488–498. Bibcode: 2007CBio...17..488M. doi: 10.1016/j.cub.2007.02.036. ISSN 0960-9822. PMID 17346968.
Further reading
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi: 10.1101/gr.143000. PMC 310948. PMID 11076863.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi: 10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi: 10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi: 10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Luboshits G, Benayahu D (2005). "MS-KIF18A, new kinesin; structure and cellular expression". Gene. 351: 19–28. doi: 10.1016/j.gene.2005.02.009. PMID 15878648.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi: 10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi: 10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode: 2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Kinesin-like protein KIF18A
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| This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it. |