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Protein-coding gene in the species Homo sapiens
Kinesin-like protein KIF17 is a
protein that in humans is encoded by the KIF17
gene.
[5]
[6] KIF17 and its close relative,
C. elegans OSM-3,
[7] are members of the
kinesin-2 family of plus-end directed
microtubule-based
motor proteins.
[8] In contrast to heterotrimeric kinesin-2 motors,
[9] however, KIF17 and OSM-3 form distinct
homodimeric complexes.
[10] Homodimeric kinesin-2 has been implicated in the transport of
NMDA receptors along
dendrites for delivery to the dendritic membrane,
[5] whereas both
heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde
intraflagellar transport (IFT) and
cilium
biogenesis.
[11]
[12]
References
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000117245 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028758 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^
a
b Setou M, Nakagawa T, Seog DH, Hirokawa N (Jun 2000). "Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport". Science. 288 (5472): 1796–802.
Bibcode:
2000Sci...288.1796S.
doi:
10.1126/science.288.5472.1796.
PMID
10846156.
-
^
"Entrez Gene: KIF17 kinesin family member 17".
-
^ Shakir MA, Fukushige T, Yasuda H, Miwa J, Siddiqui SS (July 1993). "C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein". NeuroReport. 4 (7): 891–4.
doi:
10.1097/00001756-199307000-00013.
PMID
7690265.
-
^ Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L (October 2004).
"A standardized kinesin nomenclature". J. Cell Biol. 167 (1): 19–22.
doi:
10.1083/jcb.200408113.
PMC
2041940.
PMID
15479732.
-
^ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70.
Bibcode:
1993Natur.366..268C.
doi:
10.1038/366268a0.
PMID
8232586.
S2CID
4367715.
-
^ Signor D, Wedaman KP, Rose LS, Scholey JM (February 1999).
"Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis elegans". Mol. Biol. Cell. 10 (2): 345–60.
doi:
10.1091/mbc.10.2.345.
PMC
25173.
PMID
9950681.
-
^ Snow JJ, Ou G, Gunnarson AL, Walker MR, Zhou HM, Brust-Mascher I, Scholey JM (November 2004).
"Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons". Nat. Cell Biol. 6 (11): 1109–13.
doi:
10.1038/ncb1186.
PMID
15489852.
S2CID
22416282.
-
^ Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ (July 2010).
"Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP". Nat. Cell Biol. 12 (7): 703–10.
doi:
10.1038/ncb2073.
PMC
2896429.
PMID
20526328.
Further reading
- Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000).
"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73.
doi:
10.1093/dnares/7.1.65.
PMID
10718198.
- Macho B, Brancorsini S, Fimia GM, Setou M, Hirokawa N, Sassone-Corsi P (December 2002). "CREM-dependent transcription in male germ cells controlled by a kinesin". Science. 298 (5602): 2388–90.
Bibcode:
2002Sci...298.2388M.
doi:
10.1126/science.1077265.
PMID
12493914.
S2CID
42448155.
- Guillaud L, Setou M, Hirokawa N (January 2003).
"KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons". J. Neurosci. 23 (1): 131–40.
doi:
10.1523/JNEUROSCI.23-01-00131.2003.
PMC
6742138.
PMID
12514209.
- Chennathukuzhi V, Morales CR, El-Alfy M, Hecht NB (December 2003).
"The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15566–71.
Bibcode:
2003PNAS..10015566C.
doi:
10.1073/pnas.2536695100.
PMC
307608.
PMID
14673085.
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M,
Zoghbi HY (May 2006).
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14.
doi:
10.1016/j.cell.2006.03.032.
PMID
16713569.
S2CID
13709685.