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Judith Klein-Seetharaman (born May 30, 1971) is an American-German biochemist who is a professor at the Arizona State University. Her research considers the structure-function properties of proteins using computational bio-linguistics. She was supported by the Bill & Melinda Gates Foundation to identify novel therapies to tackle HIV.

Klein-Seetharaman was born in Germany. She completed her undergraduate training at the University of Cologne, where she earned dual honours in biology and chemistry. ^{[1] [2]} After earning her doctorate, she moved to the United States, where she worked in the laboratory of Har Gobind Khorana at the Massachusetts Institute of Technology. ^{[1] [2]} Her research considered conformational changes in rhodopsin, the G protein coupled receptor. ^[3] She was a postdoctoral researcher at MIT with Harald Schwalbe, focusing on nuclear magnetic resonance spectroscopy. After eight months as a postdoc, Klein-Seetharaman moved Carnegie Mellon University where she worked with Raj Reddy in biology. She was eventually appointed to the faculty at Carnegie Mellon. ^{[1] [4]}

Klein-Seetharaman moved to the University of Pittsburgh as an assistant professor in 2002 and was promoted to associate professor in 2009. ^[1] She joined the Warwick Medical School as a professor in medicine in 2013. ^[1] She returned to the[United States in 2017, first as a professor at the Colorado School of Mines and then as a professor at the Arizona State University in 2021. ^[1] Her research looks to uncover the structure-property relationships of membrane proteins. ^[2]

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