Jane Sowden | |
---|---|
Born | Jane Caroline Sowden |
Alma mater |
University of Oxford (BA) University College London (PhD) |
Scientific career | |
Institutions | University College London Great Ormond Street Hospital for Children NHS Foundation Trust |
Thesis | Transcriptional control mechanisms regulating erythroid-specific expression of the carbonic anhydrase I gene (1991) |
Doctoral students | Adam Rutherford [1] |
Website |
iris |
Jane Caroline Sowden is a British biologist who is Professor of Developmental Biology and Genetics at the Great Ormond Street Hospital for Children NHS Foundation Trust. [2] [3] Her research investigates eye formation and repair by developing a better understanding the genetic pathways that regulate eye development.
Sowden was an undergraduate in biochemistry at the University of Oxford. [4] She moved to University College London for her doctorate where she studied the carbonic anhydrase I gene. [5]
After her PhD, Sowden moved to the Medical Research Council (MRC) human biochemical genetics unit. She was awarded a career development award in 1996, and spent four years working on retinal development at the Institute of Ophthalmology. [4] Sowden established the eye development and repair research group [6] at Great Ormond Street Hospital. [4] She looks to understand the genetic pathways that underpin eye development. She is interested in how these pathways are disrupted in patients with eye disease. [7] To explore these pathways, Sowden uses DNA sampling. [7] Childhood blindness can involve structural malformations, which occur due do disruption of biological processes. [7] The eye globe develops before birth from the embryonic optic cup. Mutations of the CHX10 gene can cause non-syndromic microphthalmia. By studying mice with CHX10 mutations Sowden looks to identify the molecular pathways that regulate relevant retinal progenitor cells. These cells undergo a number of cell divisions before producing all retinal neurons. Sowden has explored whether stem cells can be used to repair diseased retinal neurons during retinal diseases such as retinitis pigmentosa. [7] She has explored whether the ciliary epithelium can be used to generate progenitor cells for photoreceptors. She has shown that the developing retina contains a population of rod photoreceptor precursor cells, which can be transplanted into a diseased retina to restore vision. [7] [8] [9]
Her former doctoral students include Adam Rutherford. [1]
Her publications [2] [3] include:
Jane Sowden | |
---|---|
Born | Jane Caroline Sowden |
Alma mater |
University of Oxford (BA) University College London (PhD) |
Scientific career | |
Institutions | University College London Great Ormond Street Hospital for Children NHS Foundation Trust |
Thesis | Transcriptional control mechanisms regulating erythroid-specific expression of the carbonic anhydrase I gene (1991) |
Doctoral students | Adam Rutherford [1] |
Website |
iris |
Jane Caroline Sowden is a British biologist who is Professor of Developmental Biology and Genetics at the Great Ormond Street Hospital for Children NHS Foundation Trust. [2] [3] Her research investigates eye formation and repair by developing a better understanding the genetic pathways that regulate eye development.
Sowden was an undergraduate in biochemistry at the University of Oxford. [4] She moved to University College London for her doctorate where she studied the carbonic anhydrase I gene. [5]
After her PhD, Sowden moved to the Medical Research Council (MRC) human biochemical genetics unit. She was awarded a career development award in 1996, and spent four years working on retinal development at the Institute of Ophthalmology. [4] Sowden established the eye development and repair research group [6] at Great Ormond Street Hospital. [4] She looks to understand the genetic pathways that underpin eye development. She is interested in how these pathways are disrupted in patients with eye disease. [7] To explore these pathways, Sowden uses DNA sampling. [7] Childhood blindness can involve structural malformations, which occur due do disruption of biological processes. [7] The eye globe develops before birth from the embryonic optic cup. Mutations of the CHX10 gene can cause non-syndromic microphthalmia. By studying mice with CHX10 mutations Sowden looks to identify the molecular pathways that regulate relevant retinal progenitor cells. These cells undergo a number of cell divisions before producing all retinal neurons. Sowden has explored whether stem cells can be used to repair diseased retinal neurons during retinal diseases such as retinitis pigmentosa. [7] She has explored whether the ciliary epithelium can be used to generate progenitor cells for photoreceptors. She has shown that the developing retina contains a population of rod photoreceptor precursor cells, which can be transplanted into a diseased retina to restore vision. [7] [8] [9]
Her former doctoral students include Adam Rutherford. [1]
Her publications [2] [3] include: