From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Protein ajuba is a
protein that in humans is encoded by the JUB
gene .
[5]
[6]
Function
JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.
Interactions
JUB (gene) has been shown to
interact with
Stratifin
[7] and
SLC1A2 .
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000129474 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000022178 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD (Jun 1999).
"Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner" . Mol Cell Biol . 19 (6): 4379–89.
doi :
10.1128/MCB.19.6.4379 .
PMC
104397 .
PMID
10330178 .
^
"Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)" .
^ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005).
"Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Mol. Cell. Proteomics . 4 (6): 785–95.
doi :
10.1074/mcp.M500021-MCP200 .
PMID
15778465 .
^ Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D (Feb 2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci . 19 (2): 152–64.
doi :
10.1006/mcne.2001.1066 .
PMID
11860269 .
S2CID
45768895 .
Further reading
Kanungo J, Pratt SJ, Marie H, Longmore GD (2000).
"Ajuba, a Cytosolic LIM Protein, Shuttles into the Nucleus and Affects Embryonal Cell Proliferation and Fate Decisions" . Mol. Biol. Cell . 11 (10): 3299–313.
doi :
10.1091/mbc.11.10.3299 .
PMC
14993 .
PMID
11029037 .
Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D (2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci . 19 (2): 152–64.
doi :
10.1006/mcne.2001.1066 .
PMID
11860269 .
S2CID
45768895 .
Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, Braga VM (2003).
"The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin" . J. Biol. Chem . 278 (2): 1220–8.
doi :
10.1074/jbc.M205391200 .
PMID
12417594 .
Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H (2003).
"Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells" . Cell . 114 (5): 585–98.
doi :
10.1016/S0092-8674(03)00642-1 .
PMID
13678582 .
Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD (2005).
"The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration" . J. Cell Biol . 168 (5): 813–24.
doi :
10.1083/jcb.200406083 .
PMC
2171823 .
PMID
15728191 .
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005).
"Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Mol. Cell. Proteomics . 4 (6): 785–95.
doi :
10.1074/mcp.M500021-MCP200 .
PMID
15778465 .
Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD (2005).
"The LIM Protein Ajuba Regulates Phosphatidylinositol 4,5-Bisphosphate Levels in Migrating Cells through an Interaction with and Activation of PIPKIα" . Mol. Cell. Biol . 25 (10): 3956–66.
doi :
10.1128/MCB.25.10.3956-3966.2005 .
PMC
1087706 .
PMID
15870270 .
Feng Y, Longmore GD (2005).
"The LIM Protein Ajuba Influences Interleukin-1-Induced NF-κB Activation by Affecting the Assembly and Activity of the Protein Kinase Cζ/p62/TRAF6 Signaling Complex" . Mol. Cell. Biol . 25 (10): 4010–22.
doi :
10.1128/MCB.25.10.4010-4022.2005 .
PMC
1087715 .
PMID
15870274 .
Abe Y, Ohsugi M, Haraguchi K, Fujimoto J, Yamamoto T (2006).
"LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis" . FEBS Lett . 580 (3): 782–8.
doi :
10.1016/j.febslet.2005.12.096 .
PMID
16413547 .
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006).
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14.
doi :
10.1016/j.cell.2006.03.032 .
PMID
16713569 .
Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA (2008). "TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours". Mol. Cell. Endocrinol . 306 (1–2): 75–80.
doi :
10.1016/j.mce.2008.10.043 .
PMID
19041365 .
S2CID
5456314 .