J. Walter Woodbury | |
---|---|
Born | 7 August 1923 |
Died | 29 November 2017 |
Alma mater | University of Utah |
Spouse | Betty Elaine Gunderson |
Awards | Fellow, AAAS (1960) Fellow, Biophysical Society (2006) |
Scientific career | |
Institutions | 1943-45 Radiation Laboratory, MIT 1950-73 University of Washington 1973-93 University of Utah |
Academic advisors | Henry Eyring |
John Walter Woodbury (1923–2017) was an American electrophysiologist and author of the first textbook explanation of the Hodgkin-Huxley_model studies of the action potential. He applied physical and mathematical techniques to experimentally elucidate the nature of electrical excitability in cells. He was also involved in the experimental and theoretical investigations of the mechanisms of ion penetration through the ion channels in muscle membranes, the regulation of cellular acid-base balance and the control of epileptic seizures by repetitive Vagus nerve stimulation.
J. Walter Woodbury was born in St. George, Utah and grew up in Salt Lake City. He received a Bachelor of Science in Physics from the University of Utah in 1943, and from 1943 to 1945 was a staff member of the MIT Radiation Laboratory. Returning to the University of Utah after the end of WWII, he received a Master of Science degree in Physiology in 1947 followed by a Doctorate of Philosophy in Physiology in 1950, also from the University of Utah. In 1950 Woodbury joined the faculty of the University of Washington as an Instructor in the Department of Physiology, and was promoted to Assistant Professor and elected to the American Association for the Advancement of Science in 1952. [1] [2] [3] Advancing through the academic ranks he became a Full Professor in 1962, a position he held until 1973. Following a sabbatical at the University of Utah 1972-73, Woodbury accepted a position as Professor in the Department of Physiology at the University of Utah, and remained there until his retirement as Professor Emeritus in 1993, a position he held until his death. He was a son of the biologist Angus M. Woodbury. [4]
In the course of his doctoral studies Woodbury published several papers [5] [6] [7] [8] and additionally spent time with Gilbert Ling at the University of Chicago learning to pull Ling-Gerard [9] micro-electrodes and measuring the membrane potential of frog sartorius muscle. [10]
After finishing his PhD, he joined the Physiology faculty of the University of Washington (Seattle), where he used his experience in intracellular recording to study the membrane potentials in many different types of cells: spinal cord (1952 REF 6 & 7), frog sartorius muscle (1953), uterine muscle cells (1956), pregnant uterine muscle (1954 REF 8, 11), frog ventricular muscle REF 13, human heart (1957 REF 10 & 12), and cultured chick embryo heart muscle cells. Especially important was his use of a flexibly mounted ultramicroelectrode to record intracellularly from moving tissues, such as the first ever intracellular recording from the intact beating human heart [11] (Woodbury and Brady, Science, 1956 REF 10, 12). Although the first records are usually credited to Sir John Eccles, Woodbury and Harry D. Patton pioneered intracellular recording of mammalian spinal elements, including motoneurons, [12]
Other professional contributions:
J. Walter Woodbury | |
---|---|
Born | 7 August 1923 |
Died | 29 November 2017 |
Alma mater | University of Utah |
Spouse | Betty Elaine Gunderson |
Awards | Fellow, AAAS (1960) Fellow, Biophysical Society (2006) |
Scientific career | |
Institutions | 1943-45 Radiation Laboratory, MIT 1950-73 University of Washington 1973-93 University of Utah |
Academic advisors | Henry Eyring |
John Walter Woodbury (1923–2017) was an American electrophysiologist and author of the first textbook explanation of the Hodgkin-Huxley_model studies of the action potential. He applied physical and mathematical techniques to experimentally elucidate the nature of electrical excitability in cells. He was also involved in the experimental and theoretical investigations of the mechanisms of ion penetration through the ion channels in muscle membranes, the regulation of cellular acid-base balance and the control of epileptic seizures by repetitive Vagus nerve stimulation.
J. Walter Woodbury was born in St. George, Utah and grew up in Salt Lake City. He received a Bachelor of Science in Physics from the University of Utah in 1943, and from 1943 to 1945 was a staff member of the MIT Radiation Laboratory. Returning to the University of Utah after the end of WWII, he received a Master of Science degree in Physiology in 1947 followed by a Doctorate of Philosophy in Physiology in 1950, also from the University of Utah. In 1950 Woodbury joined the faculty of the University of Washington as an Instructor in the Department of Physiology, and was promoted to Assistant Professor and elected to the American Association for the Advancement of Science in 1952. [1] [2] [3] Advancing through the academic ranks he became a Full Professor in 1962, a position he held until 1973. Following a sabbatical at the University of Utah 1972-73, Woodbury accepted a position as Professor in the Department of Physiology at the University of Utah, and remained there until his retirement as Professor Emeritus in 1993, a position he held until his death. He was a son of the biologist Angus M. Woodbury. [4]
In the course of his doctoral studies Woodbury published several papers [5] [6] [7] [8] and additionally spent time with Gilbert Ling at the University of Chicago learning to pull Ling-Gerard [9] micro-electrodes and measuring the membrane potential of frog sartorius muscle. [10]
After finishing his PhD, he joined the Physiology faculty of the University of Washington (Seattle), where he used his experience in intracellular recording to study the membrane potentials in many different types of cells: spinal cord (1952 REF 6 & 7), frog sartorius muscle (1953), uterine muscle cells (1956), pregnant uterine muscle (1954 REF 8, 11), frog ventricular muscle REF 13, human heart (1957 REF 10 & 12), and cultured chick embryo heart muscle cells. Especially important was his use of a flexibly mounted ultramicroelectrode to record intracellularly from moving tissues, such as the first ever intracellular recording from the intact beating human heart [11] (Woodbury and Brady, Science, 1956 REF 10, 12). Although the first records are usually credited to Sir John Eccles, Woodbury and Harry D. Patton pioneered intracellular recording of mammalian spinal elements, including motoneurons, [12]
Other professional contributions: