Isaac was one of the patriarchs of the Abrahamic faiths.

Isaac may also refer to:

• Isaac (name), including a list of people and fictional characters with the given name or surname of Isaac and its variants

• International Society for Analysis, its Applications and Computation
• International Society for Augmentative and Alternative Communication

• Great Isaac Cay, Bahamas
• Issac, Dordogne, Nouvelle-Aquitaine, France
• Isaac River, Australia
• Isaac Region, Australia
• Isaac's Harbour, Nova Scotia, Canada
• Isaac's Harbour North, Nova Scotia, Canada
• Port Isaac, Cornwall, United Kingdom

• Hurricane Isaac (2012), a Category 1 hurricane that hit the Greater New Orleans area on August 29, 2012
• Infrared Spectrometer And Array Camera (ISAAC)), an instrument on the Very Large Telescope
• ISAAC (cipher), a cryptographically secure pseudorandom number generator
• ISAAC (comics), a supercomputer in Marvel Comics
• Isaac (talk show), a talk show hosted by Isaac Mizrahi
• Tropical Storm Isaac, a designation used for various tropical cyclones
• "Isaac" (song), a song by Hollyn
• "Isaac", a song by Madonna, from her album Confessions on a Dance Floor
• Isaac, the northeasternmost country in the Fire Emblem universe continent Jugdral

• Isaacs (disambiguation)
• Isaaq, a Somali clan
• Ishak (disambiguation)
• International Symposium on Symbolic and Algebraic Computation (ISSAC)
• Izak (disambiguation)
• Izzy (disambiguation)
• Zack (disambiguation)

This disambiguation page lists articles associated with the title Isaac.
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