Names | |
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Preferred IUPAC name
Bis[(4R,4aS,6R,7S,7aR)-2,4,7-trimethyloctahydro-1H-cyclopenta[c]pyridin-6-yl] (1R,2R,3S,4S)-2,4-bis(4-hydroxy-3-methoxyphenyl)cyclobutane-1,3-dicarboxylate | |
Identifiers | |
3D model (
JSmol)
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ChEMBL | |
ChemSpider | |
PubChem
CID
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Properties | |
C42H58N2O8 | |
Molar mass | 718.932 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Incarvillateine is a complex monoterpene alkaloid that is a derivative of α- truxillic acid. It can be isolated from the plant genus Incarvillea.
Incarvillateine isolated from Incarvillea sinensis has demonstrated significant analgesic activity when compared to the opiate alkaloid morphine. [1]
Incarvillateine's pain-killing effect was partially blocked by administration of naloxone, [2] norbinaltorphimine and beta-funaltrexamine, [3] which are receptor antagonists with varying selectivity for mu and kappa opioid receptors. Naltrindole, a delta opioid receptor antagonist, did not counteract the analgesic activity of incarvillateine. [3]
These findings indicate that incarvillateine may possess opioidergic receptor activity, but it is worthy to note that some studies indicate that naloxone was ineffective at countering incarvillateine's analgesic activity. [4]
Incarvillateine's antinociceptive effect was blocked by the administration of adenosine receptor antagonists such as theophylline. This suggests that incarvillateine's main mechanism of action is mediated through the adenosine receptor. [4]
Names | |
---|---|
Preferred IUPAC name
Bis[(4R,4aS,6R,7S,7aR)-2,4,7-trimethyloctahydro-1H-cyclopenta[c]pyridin-6-yl] (1R,2R,3S,4S)-2,4-bis(4-hydroxy-3-methoxyphenyl)cyclobutane-1,3-dicarboxylate | |
Identifiers | |
3D model (
JSmol)
|
|
ChEMBL | |
ChemSpider | |
PubChem
CID
|
|
| |
| |
Properties | |
C42H58N2O8 | |
Molar mass | 718.932 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Incarvillateine is a complex monoterpene alkaloid that is a derivative of α- truxillic acid. It can be isolated from the plant genus Incarvillea.
Incarvillateine isolated from Incarvillea sinensis has demonstrated significant analgesic activity when compared to the opiate alkaloid morphine. [1]
Incarvillateine's pain-killing effect was partially blocked by administration of naloxone, [2] norbinaltorphimine and beta-funaltrexamine, [3] which are receptor antagonists with varying selectivity for mu and kappa opioid receptors. Naltrindole, a delta opioid receptor antagonist, did not counteract the analgesic activity of incarvillateine. [3]
These findings indicate that incarvillateine may possess opioidergic receptor activity, but it is worthy to note that some studies indicate that naloxone was ineffective at countering incarvillateine's analgesic activity. [4]
Incarvillateine's antinociceptive effect was blocked by the administration of adenosine receptor antagonists such as theophylline. This suggests that incarvillateine's main mechanism of action is mediated through the adenosine receptor. [4]