Importin subunit alpha-6 is a
protein that in humans is encoded by the KPNA5gene.[3]
The transport of
molecules between the nucleus and the cytoplasm in
eukaryotic cells is mediated by the
nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic
amino acid sequences known as
nuclear localization signals (NLSs).
KPNA5 protein belongs to the
importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus[4]
Sharova N, Bukrinskaya A (1991). "p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells". AIDS Res. Hum. Retroviruses. 7 (3): 303–6.
doi:
10.1089/aid.1991.7.303.
PMID2064827.
Importin subunit alpha-6 is a
protein that in humans is encoded by the KPNA5gene.[3]
The transport of
molecules between the nucleus and the cytoplasm in
eukaryotic cells is mediated by the
nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic
amino acid sequences known as
nuclear localization signals (NLSs).
KPNA5 protein belongs to the
importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus[4]
Sharova N, Bukrinskaya A (1991). "p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells". AIDS Res. Hum. Retroviruses. 7 (3): 303–6.
doi:
10.1089/aid.1991.7.303.
PMID2064827.