From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Importin subunit alpha-5 is a
protein that in humans is encoded by the KPNA1
gene .
[5]
Importin subunit alpha-5 has been shown to
interact with
KPNB1
[6]
[7] and
UBR5 .
[8]
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000114030 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000022905 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Cortes P, Ye ZS, Baltimore D (Sep 1994).
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Bibcode :
1994PNAS...91.7633C .
doi :
10.1073/pnas.91.16.7633 .
PMC
44456 .
PMID
8052633 .
^ Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (Nov 1999).
"Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import" . Mol. Cell. Biol . 19 (11). UNITED STATES: 7782–91.
doi :
10.1128/mcb.19.11.7782 .
ISSN
0270-7306 .
PMC
84838 .
PMID
10523667 .
^ Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import". J. Mol. Biol . 266 (4). ENGLAND: 722–32.
doi :
10.1006/jmbi.1996.0801 .
ISSN
0022-2836 .
PMID
9102465 .
^ Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002).
"EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response" . J. Biol. Chem . 277 (29). United States: 26468–78.
doi :
10.1074/jbc.M203527200 .
hdl :
1885/64590 .
ISSN
0021-9258 .
PMID
12011095 .
Bukrinsky MI, Haffar OK (2004).
"HIV-1 nuclear import: in search of a leader" . Front. Biosci . 2 (4): d578–87.
doi :
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PMID
9366553 .
Bukrinsky MI, Haffar OK (1998).
"HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr" . Mol. Med . 4 (3): 138–43.
doi :
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PMC
2230352 .
PMID
9562972 .
Kino T, Pavlakis GN (2004).
"Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1" . DNA Cell Biol . 23 (4): 193–205.
doi :
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PMID
15142377 .
Bukrinsky MI, Sharova N, Dempsey MP, et al. (1992).
"Active nuclear import of human immunodeficiency virus type 1 preintegration complexes" . Proc. Natl. Acad. Sci. U.S.A . 89 (14): 6580–4.
Bibcode :
1992PNAS...89.6580B .
doi :
10.1073/pnas.89.14.6580 .
PMC
49545 .
PMID
1631159 .
Sharova N, Bukrinskaya A (1991). "p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells". AIDS Res. Hum. Retroviruses . 7 (3): 303–6.
doi :
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PMID
2064827 .
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"Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr" . J. Virol . 69 (12): 7909–16.
doi :
10.1128/JVI.69.12.7909-7916.1995 .
PMC
189735 .
PMID
7494303 .
Gallay P, Swingler S, Song J, et al. (1995).
"HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase" . Cell . 83 (4): 569–76.
doi :
10.1016/0092-8674(95)90097-7 .
PMID
7585960 .
S2CID
15536328 .
Moroianu J, Hijikata M, Blobel G, Radu A (1995).
"Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins" . Proc. Natl. Acad. Sci. U.S.A . 92 (14): 6532–6.
Bibcode :
1995PNAS...92.6532M .
doi :
10.1073/pnas.92.14.6532 .
PMC
41552 .
PMID
7604027 .
Freed EO, Englund G, Martin MA (1995).
"Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection" . J. Virol . 69 (6): 3949–54.
doi :
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PMC
189124 .
PMID
7745752 .
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Bibcode :
1995Sci...268.1049W .
doi :
10.1126/science.7754385 .
PMID
7754385 .
O'Neill RE, Palese P (1995). "NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein". Virology . 206 (1): 116–25.
doi :
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PMID
7831767 .
Gallay P, Swingler S, Aiken C, Trono D (1995).
"HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator" . Cell . 80 (3): 379–88.
doi :
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PMID
7859280 .
S2CID
15064293 .
Moroianu J, Blobel G, Radu A (1995).
"Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes" . Proc. Natl. Acad. Sci. U.S.A . 92 (6): 2008–11.
Bibcode :
1995PNAS...92.2008M .
doi :
10.1073/pnas.92.6.2008 .
PMC
42412 .
PMID
7892216 .
von Schwedler U, Kornbluth RS, Trono D (1994).
"The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes" . Proc. Natl. Acad. Sci. U.S.A . 91 (15): 6992–6.
Bibcode :
1994PNAS...91.6992V .
doi :
10.1073/pnas.91.15.6992 .
PMC
44324 .
PMID
8041734 .
Heinzinger NK, Bukinsky MI, Haggerty SA, et al. (1994).
"The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells" . Proc. Natl. Acad. Sci. U.S.A . 91 (15): 7311–5.
Bibcode :
1994PNAS...91.7311H .
doi :
10.1073/pnas.91.15.7311 .
PMC
44389 .
PMID
8041786 .
Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993).
"A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells" . Nature . 365 (6447): 666–9.
Bibcode :
1993Natur.365..666B .
doi :
10.1038/365666a0 .
PMC
9524217 .
PMID
8105392 .
S2CID
25678 .
Dubrovsky L, Ulrich P, Nuovo GJ, et al. (1996).
"Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention" . Mol. Med . 1 (2): 217–30.
doi :
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PMC
2229944 .
PMID
8529100 .
Gallay P, Stitt V, Mundy C, et al. (1996).
"Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import" . J. Virol . 70 (2): 1027–32.
doi :
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PMC
189908 .
PMID
8551560 .
Bukrinskaya AG, Ghorpade A, Heinzinger NK, et al. (1996).
"Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA" . Proc. Natl. Acad. Sci. U.S.A . 93 (1): 367–71.
Bibcode :
1996PNAS...93..367B .
doi :
10.1073/pnas.93.1.367 .
PMC
40239 .
PMID
8552640 .