Names | |
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Preferred IUPAC name
9-[(3-Methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one | |
Other names
Ammidin
Marmelosin Pentosalen 8-Isoamylenoxypsoralen 8-Isopentenyloxypsoralene | |
Identifiers | |
3D model (
JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.006.893 |
KEGG | |
PubChem
CID
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UNII | |
CompTox Dashboard (
EPA)
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Properties | |
C16H14O4 | |
Molar mass | 270.28 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Imperatorin is a furocoumarin and a phytochemical that has been isolated from Urena lobata L. ( Malvaceae), Angelica archangelica, [1] Angelica dahurica, [2] Glehnia littoralis, [3] Saposhnikovia divaricata, [4] Cnidium monnieri, [5] Incarvillea younghusbandii, [6] and Zanthoxylum americanum mill. [7] It is biosynthesized from umbelliferone, a coumarin derivative. [8]
The procedure for the isolation of imperatorin from Urena lobata involves exhaustively extracting under reflux with benzene the air-dried and pulverised roots followed by separation by column chromatography. [9]
Imperatorin was identified from a Bioactive Molecules library in a high throughput screening experiment for inhibitors of the phosphodiesterase PDE4. It displays a significant preference for PDE4B over PDE4A. [10] Imperatorin has been shown to have anti-inflammatory activity in chondrocytes. [11] Imperatorin treatment inhibits the expression of iNOS and suppresses the production of NO in osteoarthritic chondrocytes. [11]
Names | |
---|---|
Preferred IUPAC name
9-[(3-Methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one | |
Other names
Ammidin
Marmelosin Pentosalen 8-Isoamylenoxypsoralen 8-Isopentenyloxypsoralene | |
Identifiers | |
3D model (
JSmol)
|
|
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.006.893 |
KEGG | |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C16H14O4 | |
Molar mass | 270.28 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Imperatorin is a furocoumarin and a phytochemical that has been isolated from Urena lobata L. ( Malvaceae), Angelica archangelica, [1] Angelica dahurica, [2] Glehnia littoralis, [3] Saposhnikovia divaricata, [4] Cnidium monnieri, [5] Incarvillea younghusbandii, [6] and Zanthoxylum americanum mill. [7] It is biosynthesized from umbelliferone, a coumarin derivative. [8]
The procedure for the isolation of imperatorin from Urena lobata involves exhaustively extracting under reflux with benzene the air-dried and pulverised roots followed by separation by column chromatography. [9]
Imperatorin was identified from a Bioactive Molecules library in a high throughput screening experiment for inhibitors of the phosphodiesterase PDE4. It displays a significant preference for PDE4B over PDE4A. [10] Imperatorin has been shown to have anti-inflammatory activity in chondrocytes. [11] Imperatorin treatment inhibits the expression of iNOS and suppresses the production of NO in osteoarthritic chondrocytes. [11]