From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Insulin receptor substrate 4 is a
protein that in humans is encoded by the IRS4
gene .
[5]
[6]
[7]
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.
[7]
Interactions
IRS4 has been shown to
interact with
CRK
[8]
[9] and
NISCH .
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000133124 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000054667 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE (Sep 1997).
"A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family" . J Biol Chem . 272 (34): 21403–7.
doi :
10.1074/jbc.272.34.21403 .
PMID
9261155 .
^ Fantin VR, Sparling JD, Slot JW, Keller SR, Lienhard GE, Lavan BE (May 1998).
"Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells" . J Biol Chem . 273 (17): 10726–32.
doi :
10.1074/jbc.273.17.10726 .
PMID
9553137 .
^
a
b
"Entrez Gene: IRS4 insulin receptor substrate 4" .
^ Karas M, Koval A P, Zick Y, LeRoith D (May 2001).
"The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II" .
Endocrinology . 142 (5). United States: 1835–40.
doi :
10.1210/endo.142.5.8135 .
ISSN
0013-7227 .
PMID
11316748 .
^ Koval AP, Karas M, Zick Y, LeRoith D (Jun 1998).
"Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction" . J. Biol. Chem . 273 (24). UNITED STATES: 14780–7.
doi :
10.1074/jbc.273.24.14780 .
ISSN
0021-9258 .
PMID
9614078 .
^ Sano H, Liu Simon C H, Lane William S, Piletz John E, Lienhard Gustav E (May 2002).
"Insulin receptor substrate 4 associates with the protein IRAS" . J. Biol. Chem . 277 (22). United States: 19439–47.
doi :
10.1074/jbc.M111838200 .
ISSN
0021-9258 .
PMID
11912194 .
Further reading
White MF (1999). "The IRS-signalling system: a network of docking proteins that mediate insulin action". Mol. Cell. Biochem . 182 (1–2): 3–11.
doi :
10.1023/A:1006806722619 .
PMID
9609109 .
S2CID
32623861 .
Koval AP, Karas M, Zick Y, LeRoith D (1998).
"Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction" . J. Biol. Chem . 273 (24): 14780–7.
doi :
10.1074/jbc.273.24.14780 .
PMID
9614078 .
Uchida T, Myers MG, White MF (2000).
"IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis" . Mol. Cell. Biol . 20 (1): 126–38.
doi :
10.1128/MCB.20.1.126-138.2000 .
PMC
85068 .
PMID
10594015 .
Karas M, Koval AP, Zick Y, LeRoith D (2001).
"The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II" . Endocrinology . 142 (5): 1835–40.
doi :
10.1210/en.142.5.1835 .
PMID
11316748 .
Sano H, Liu SC, Lane WS, et al. (2002).
"Insulin receptor substrate 4 associates with the protein IRAS" . J. Biol. Chem . 277 (22): 19439–47.
doi :
10.1074/jbc.M111838200 .
PMID
11912194 .
Krebs DL, Uren RT, Metcalf D, et al. (2002).
"SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation" . Mol. Cell. Biol . 22 (13): 4567–78.
doi :
10.1128/MCB.22.13.4567-4578.2002 .
PMC
133908 .
PMID
12052866 .
Schreyer S, Ledwig D, Rakatzi I, et al. (2003).
"Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor" . Endocrinology . 144 (4): 1211–8.
doi :
10.1210/en.2002-220723 .
PMID
12639902 .
Escribano O, Fernández-Moreno MD, Zueco JA, et al. (2003).
"Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver" . Hepatology . 37 (6): 1461–9.
doi :
10.1053/jhep.2003.50245 .
PMID
12774026 .
S2CID
20484894 .
Yen HW, Jakimiuk AJ, Munir I, Magoffin DA (2005).
"Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries" . Mol. Hum. Reprod . 10 (7): 473–9.
doi :
10.1093/molehr/gah066 .
PMID
15155816 .
Hinsby AM, Olsen JV, Mann M (2004).
"Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4" . J. Biol. Chem . 279 (45): 46438–47.
doi :
10.1074/jbc.M404537200 .
PMID
15316024 .
Jin J, Smith FD, Stark C, et al. (2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50.
Bibcode :
2004CBio...14.1436J .
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
S2CID
2371325 .
Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (2004).
"Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation" . J. Biol. Chem . 279 (45): 46588–94.
doi :
10.1074/jbc.M408067200 .
PMID
15331607 .
Qiu H, Zappacosta F, Su W, et al. (2005).
"Interaction between Brk kinase and insulin receptor substrate-4" . Oncogene . 24 (36): 5656–64.
doi :
10.1038/sj.onc.1208721 .
PMID
15870689 .
Cuevas EP, Escribano O, Chiloeches A, et al. (2007). "Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation". J. Hepatol . 46 (6): 1089–98.
doi :
10.1016/j.jhep.2007.01.031 .
PMID
17408801 .