Interleukin-12 subunit alpha (IL-12 p35) is a
protein that in humans is encoded by the IL12Agene.[5]
Function
This gene encodes a subunit of the
cytokineInterleukin 12 (IL-12) that acts on
T and
natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked
heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-dependent induction of
interferon gamma (IFN-γ), and is important for the differentiation of both
Th1 and
Th2 cells. The responses of
lymphocytes to this cytokine are mediated by the activator of transcription protein
STAT4. Nitric oxide synthase 2A (
NOS2A/NOS2) is found to be required for the signaling process of this cytokine in
innate immunity.[6]
Airoldi I, Guglielmino R, Carra G, Corcione A, Gerosa F, Taborelli G, Trinchieri G, Pistoia V (2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 (4): 434–42.
PMID11940489.
Sharma V, Knobloch TJ, Benjamin D (1995). "Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines". Biochem. Biophys. Res. Commun. 208 (2): 704–13.
doi:
10.1006/bbrc.1995.1395.
PMID7695626.
Radrizzani M, Accornero P, Amidei A, Aiello A, Delia D, Kurrle R, Colombo MP (1995). "IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation". Cell. Immunol. 161 (1): 14–21.
doi:
10.1006/cimm.1995.1003.
PMID7867080.
Interleukin-12 subunit alpha (IL-12 p35) is a
protein that in humans is encoded by the IL12Agene.[5]
Function
This gene encodes a subunit of the
cytokineInterleukin 12 (IL-12) that acts on
T and
natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked
heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-dependent induction of
interferon gamma (IFN-γ), and is important for the differentiation of both
Th1 and
Th2 cells. The responses of
lymphocytes to this cytokine are mediated by the activator of transcription protein
STAT4. Nitric oxide synthase 2A (
NOS2A/NOS2) is found to be required for the signaling process of this cytokine in
innate immunity.[6]
Airoldi I, Guglielmino R, Carra G, Corcione A, Gerosa F, Taborelli G, Trinchieri G, Pistoia V (2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 (4): 434–42.
PMID11940489.
Sharma V, Knobloch TJ, Benjamin D (1995). "Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines". Biochem. Biophys. Res. Commun. 208 (2): 704–13.
doi:
10.1006/bbrc.1995.1395.
PMID7695626.
Radrizzani M, Accornero P, Amidei A, Aiello A, Delia D, Kurrle R, Colombo MP (1995). "IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation". Cell. Immunol. 161 (1): 14–21.
doi:
10.1006/cimm.1995.1003.
PMID7867080.