The second federal electoral district of Tlaxcala (Distrito electoral federal 02 de Tlaxcala) is one of the 300 electoral districts into which Mexico is divided for elections to the federal Chamber of Deputies and one of three such districts in the state of Tlaxcala.

It elects one deputy to the lower house of Congress for each three-year legislative period, by means of the first-past-the-post system. Votes cast in this district also count towards the calculation of proportional representation ("plurinominal") deputies elected from the fourth region. ^{[1] [2]}

The district occupies the central and western portion of the state and its head town (cabecera distrital), where results from individual polling stations are gathered together and collated, is the city of Tlaxcala de Xicohténcatl, the state capital. ^[3]

National parties
Current
	PAN
	PRI
	PT
	PVEM
	MC
	Morena
Defunct or local only
	PLM
	PNR
	PRM
	PPS
	PARM
	Convergencia
	PANAL
	PSD
	PES
	PRD

Second federal electoral district of Tlaxcala

Election	Deputy	Party	Legislature	Term
1970	María de los Ángeles Grant Munive [ es]		48th Congress	1970–1973
1973	Aurelio Zamora García		49th Congress	1973–1976
1976	Antonio Vega García		50th Congress	1976–1979
1979	Beatriz Paredes Rangel		51st Congress	1979–1982
1982	Alma Gracia de Zamora		52nd Congress	1982–1985
1985	Samuel Quiroz de la Vega [ es]		53rd Congress	1985–1988
1988	Jesús Pelecastre Rojas		54th Congress	1988–1991
1991	Álvaro Salazar Lozano		55th Congress	1991–1994
1994	Alfonso Sánchez Anaya		56th Congress	1994–1997
1997	Enrique Padilla Sánchez		57th Congress	1997–2000
2000	Héctor Ortiz Ortiz Eréndira Cova Brindis		58th Congress	2000–2001 2001–2003
2003	Florentino Domínguez Ordóñez		59th Congress	2003–2006
2006	Adolfo Escobar Jardínez [4] [a] María Ofelia Malcos Alfaro Adolfo Escobar Jardínez [b] María Ofelia Malcos Alfaro		60th Congress	2006–2007 2007 2007–2009 2009
2009	Julián Velázquez Llorente		61st Congress	2009–2012
2012	Humberto Vega Vázquez		62nd Congress	2012–2015
2015	Anabel Alvarado Varela		63rd Congress	2015–2018
2018	Rubén Terán Águila		64th Congress	2018–2021
2021	Irma Yordana Garay Loredo [5] [6]		65th Congress	2021–2024
2024	Raymundo Vázquez Conchas [7]		66th Congress	2024–2027

19°18′N 98°14′W / 19.300°N 98.233°W / 19.300; -98.233