From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase, Intestinal cell kinase or ICK
[5] is an
enzyme that in humans is encoded by the ICK
gene.
[6]
[7]
Eukaryotic
protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both
serine/threonine and
tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual
phosphorylation site found in
mitogen-activating protein (MAP) kinases. The protein localizes to the
intestinal crypt region and is thought to be important in
intestinal epithelial
cell proliferation and
differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same
isoform, have been identified.
[7]
References
Further reading
- Nagase T, Ishikawa K, Suyama M, et al. (1999).
"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70.
doi:
10.1093/dnares/6.1.63.
PMID
10231032.
- Togawa K, Yan YX, Inomoto T, et al. (2000). "Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases". J. Cell. Physiol. 183 (1): 129–39.
doi:
10.1002/(SICI)1097-4652(200004)183:1<129::AID-JCP15>3.0.CO;2-S.
PMID
10699974.
S2CID
41279862.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003).
"The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11.
Bibcode:
2003Natur.425..805M.
doi:
10.1038/nature02055.
PMID
14574404.
- Colland F, Jacq X, Trouplin V, et al. (2004).
"Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32.
doi:
10.1101/gr.2334104.
PMC
442148.
PMID
15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Fu Z, Schroeder MJ, Shabanowitz J, et al. (2005).
"Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase". Mol. Cell. Biol. 25 (14): 6047–64.
doi:
10.1128/MCB.25.14.6047-6064.2005.
PMC
1168834.
PMID
15988018.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
Bibcode:
2005Natur.437.1173R.
doi:
10.1038/nature04209.
PMID
16189514.
S2CID
4427026.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65.
doi:
10.1101/gr.4039406.
PMC
1356129.
PMID
16344560.