Non-histone chromosomal protein HMG-14 is a
protein that in humans is encoded by the HMGN1gene.[5][6][7]
Function
Chromosomal protein HMG14 and its close analog
HMG17 (MIM 163910) bind to the inner side of the
nucleosomal DNA, potentially altering the interaction between the DNA and the
histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique
chromatin conformation.[8] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[7]
Zou Y, Jiang X, Wang Y (May 2004). "Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells". Biochemistry. 43 (20): 6322–9.
doi:
10.1021/bi0362828.
PMID15147216.
Non-histone chromosomal protein HMG-14 is a
protein that in humans is encoded by the HMGN1gene.[5][6][7]
Function
Chromosomal protein HMG14 and its close analog
HMG17 (MIM 163910) bind to the inner side of the
nucleosomal DNA, potentially altering the interaction between the DNA and the
histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique
chromatin conformation.[8] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[7]
Zou Y, Jiang X, Wang Y (May 2004). "Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells". Biochemistry. 43 (20): 6322–9.
doi:
10.1021/bi0362828.
PMID15147216.