Hirao coupling | |
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Named after | Toshikazu Hirao |
Reaction type | Coupling reaction |
The Hirao coupling (also called the Hirao reaction or the Hirao cross-coupling) is the chemical reaction involving the palladium- catalyzed cross-coupling of a dialkyl phosphite and an aryl halide to form a phosphonate. [1] [2] [3] This reaction is named after Toshikazu Hirao and is related to the Michaelis-Arbuzov reaction. In contrast to the classic Michaelis-Arbuzov reaction, which is limited to alkyl phosphonates, the Hirao coupling can also deliver aryl phosphonates.
Hirao coupling | |
---|---|
Named after | Toshikazu Hirao |
Reaction type | Coupling reaction |
The Hirao coupling (also called the Hirao reaction or the Hirao cross-coupling) is the chemical reaction involving the palladium- catalyzed cross-coupling of a dialkyl phosphite and an aryl halide to form a phosphonate. [1] [2] [3] This reaction is named after Toshikazu Hirao and is related to the Michaelis-Arbuzov reaction. In contrast to the classic Michaelis-Arbuzov reaction, which is limited to alkyl phosphonates, the Hirao coupling can also deliver aryl phosphonates.