Hepatitis B virus PRE 1151–1410 | |
---|---|
Identifiers | |
Rfam | RF02816 |
Other data | |
Domain(s) | Viruses |
GO | GO:0051168, GO:0043484 |
SO | SO:0005836 |
PDB structures | PDBe |
Hepatitis B virus PRE 1151–1410 (HBV post-transcriptional regulatory element, nucleotides 1151–1410) is a part of 500 base pair long HBV PRE, that has been proposed to be the hepatitis B virus (HBV) RNA export element. [1] [2] [3] However, the function is controversial and new regulatory elements have been predicted within PRE. [4] PRE 1151–1410 enhances nuclear export of intronless transcripts and represses the splicing mechanism to a comparable degree to that of the full-length PRE. Hence it was proposed to be the core HBV PRE element. [4] PRE1151–1410 contains 3 known regulatory elements: PRE SL-alpha (nucleotides 1292–1321), [5] human La protein binding site (nucleotide 1275–1291), [6] SRE-1 (nucleotides 1252–1348). [7]
Hepatitis B virus PRE 1151–1410 | |
---|---|
Identifiers | |
Rfam | RF02816 |
Other data | |
Domain(s) | Viruses |
GO | GO:0051168, GO:0043484 |
SO | SO:0005836 |
PDB structures | PDBe |
Hepatitis B virus PRE 1151–1410 (HBV post-transcriptional regulatory element, nucleotides 1151–1410) is a part of 500 base pair long HBV PRE, that has been proposed to be the hepatitis B virus (HBV) RNA export element. [1] [2] [3] However, the function is controversial and new regulatory elements have been predicted within PRE. [4] PRE 1151–1410 enhances nuclear export of intronless transcripts and represses the splicing mechanism to a comparable degree to that of the full-length PRE. Hence it was proposed to be the core HBV PRE element. [4] PRE1151–1410 contains 3 known regulatory elements: PRE SL-alpha (nucleotides 1292–1321), [5] human La protein binding site (nucleotide 1275–1291), [6] SRE-1 (nucleotides 1252–1348). [7]