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(Redirected from Hans Gruneberg)

Hans Grüneberg
FRS
Hans Grüneberg in 1952
Born(1907-05-26)26 May 1907
WuppertalElberfeld, Germany
Died23 October 1982(1982-10-23) (aged 75)
Other namesHans Grueneberg, Hans Gruneberg
Education University of Bonn (MD), University of Berlin (PhD), University of London (DSc)
Known forDescription of siderocytes and sideroblasts
Scientific career
FieldsMouse genetics
Institutions Royal Army Medical Corps, University College London
Patrons J. B. S. Haldane, Sir Henry Dale

Hans Grüneberg FRS [1] (26 May 1907 – 23 October 1982), whose name was also written as Hans Grueneberg and Hans Gruneberg, was a British geneticist. Grüneberg was born in WuppertalElberfeld in Germany. He obtained an MD from the University of Bonn, a PhD in biology from the University of Berlin and a DSc from the University of London. He arrived in London in 1933, at the invitation of J.B.S. Haldane and Sir Henry Dale.

He was elected a Fellow of the Royal Society in 1956. [1] Most of his work focused on mouse genetics, [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] in which his speciality was the study of pleiotropic effects of mutations on the development of the mouse skeleton.

He was the first person to describe siderocytes and sideroblasts, atypical nucleated erythrocytes with granules of iron accumulated in perinuclear mitochondria. [14] This he reported in the journal Nature. [15] [16] [17] The Grüneberg ganglion, [18] an olfactory ganglion in rodents, was first described by Hans Grueneberg in 1973.

Career

  • Honorary Research Assistant, University College London, 1933–38
  • Moseley Research Student of Royal Society, 1938–42
  • Captain, Royal Army Medical Corps, 1942–46
  • Reader in Genetics, University College London, 1946–55
  • Honorary Director of the Medical Research Council Experimental Genetics Unit at University College London, 1955–1972
  • Professor of Genetics University College London, 1956–1974
  • Affiliated with the Department of Pathology, Mount Vernon Hospital, Northwood, Middlesex
  • Emeritus Professor University College London, from retirement, 1974

Books

  • 1947. Animal genetics and medicine. Hamish Hamilton, London.
  • 1952. The genetics of the mouse. 2nd ed, revised and enlarged. Nijhoff, The Hague.
  • 1963. The pathology of development: a study of inherited skeletal disorders in animals. Wiley, London.

References

  1. ^ a b Lewis, Dan; Hunt, D. M. (1984). "Hans Grüneberg. 26 May 1907 – 23 October 1982". Biographical Memoirs of Fellows of the Royal Society. 30: 226–247. doi: 10.1098/rsbm.1984.0008. JSTOR  769826. PMID  11616003. S2CID  7536917.
  2. ^ Grüneberg, H.; Wickramaratne, G. A. (1974). "A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch)". Journal of Embryology and Experimental Morphology. 31 (1): 207–222. PMID  4819561.
  3. ^ Grüneberg, H.; Lee, A. J. (1973). "The anatomy and development of brachypodism in the mouse". Journal of Embryology and Experimental Morphology. 30 (1): 119–141. PMID  4729943.
  4. ^ Grüneberg, H. (1971). "Exocrine glands and the Chievitz organ of some mouse mutants". Journal of Embryology and Experimental Morphology. 25 (2): 247–261. PMID  5088022.
  5. ^ Grüneberg, H. (1971). "The glandular aspects of the tabby syndrome in the mouse". Journal of Embryology and Experimental Morphology. 25 (1): 1–19. PMID  5548211.
  6. ^ Grüneberg, H. (1969). "Threshold phenomena versus cell heredity in the manifestation of sex-linked genes in mammals". Journal of Embryology and Experimental Morphology. 22 (2): 145–179. PMID  5361553.
  7. ^ Grüneberg, H. (1966). "More about the tabby mouse and about the Lyon hypothesis". Journal of Embryology and Experimental Morphology. 16 (3): 569–590. PMID  5962700.
  8. ^ Grüneberg, H. (1966). "The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis". Journal of Embryology and Experimental Morphology. 15 (2): 223–244. PMID  5959976.
  9. ^ Grüneberg, H. (1965). "Genes and genotypes affecting the teeth of the mouse". Journal of Embryology and Experimental Morphology. 14 (2): 137–159. PMID  5893447.
  10. ^ Gruneberg, H. (1958). "Genetical studies on the skeleton of the mouse. XXIII. The development of brachyury and anury". Journal of Embryology and Experimental Morphology. 6 (3): 424–443. PMID  13575656.
  11. ^ Gruneberg, H. (1958). "Genetical studies on the skeleton of the mouse. XXII. The development of Danforth's short-tail". Journal of Embryology and Experimental Morphology. 6 (1): 124–148. PMID  13539275.
  12. ^ Grüneberg, H.; Burnett, J. B.; Snell, G. D. (1941). "The Origin of Jerker, a New Gene Mutation of the House Mouse, and Linkage Studies Made with It". Proceedings of the National Academy of Sciences of the United States of America. 27 (12): 562–565. Bibcode: 1941PNAS...27..562G. doi: 10.1073/pnas.27.12.562. PMC  1078382. PMID  16588504.
  13. ^ Grüneberg, H. (1939). "Inherited Macrocytic Anemias in the House Mouse". Genetics. 24 (6): 777–810. doi: 10.1093/genetics/24.6.777. PMC  1209073. PMID  17246952.
  14. ^ medical-dictionary
  15. ^ Grüneberg, H. (1970). "Is there a viral component in the genetic background?". Nature. 225 (5227): 39–41. Bibcode: 1970Natur.225...39G. doi: 10.1038/225039a0. PMID  5410193. S2CID  4269949.
  16. ^ Gruneberg, H. (1956). "A ventral ectodermal ridge of the tail in mouse embryos". Nature. 177 (4513): 787–788. Bibcode: 1956Natur.177..787G. doi: 10.1038/177787b0. PMID  13321960. S2CID  4178438.
  17. ^ Grüneberg, H. (1954). "Variation Within Inbred Strains of Mice". Nature. 173 (4406): 674–676. Bibcode: 1954Natur.173..674G. doi: 10.1038/173674a0. PMID  13165620. S2CID  4257744.
  18. ^ Grüneberg, H. (1973). "A ganglion probably belonging to the N. Terminalis system in the nasal mucosa of the mouse". Zeitschrift für Anatomie und Entwicklungsgeschichte. 140 (1): 39–52. doi: 10.1007/BF00520716. PMID  4749131. S2CID  10216579.

External links

Sources

From Wikipedia, the free encyclopedia
(Redirected from Hans Gruneberg)

Hans Grüneberg
FRS
Hans Grüneberg in 1952
Born(1907-05-26)26 May 1907
WuppertalElberfeld, Germany
Died23 October 1982(1982-10-23) (aged 75)
Other namesHans Grueneberg, Hans Gruneberg
Education University of Bonn (MD), University of Berlin (PhD), University of London (DSc)
Known forDescription of siderocytes and sideroblasts
Scientific career
FieldsMouse genetics
Institutions Royal Army Medical Corps, University College London
Patrons J. B. S. Haldane, Sir Henry Dale

Hans Grüneberg FRS [1] (26 May 1907 – 23 October 1982), whose name was also written as Hans Grueneberg and Hans Gruneberg, was a British geneticist. Grüneberg was born in WuppertalElberfeld in Germany. He obtained an MD from the University of Bonn, a PhD in biology from the University of Berlin and a DSc from the University of London. He arrived in London in 1933, at the invitation of J.B.S. Haldane and Sir Henry Dale.

He was elected a Fellow of the Royal Society in 1956. [1] Most of his work focused on mouse genetics, [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] in which his speciality was the study of pleiotropic effects of mutations on the development of the mouse skeleton.

He was the first person to describe siderocytes and sideroblasts, atypical nucleated erythrocytes with granules of iron accumulated in perinuclear mitochondria. [14] This he reported in the journal Nature. [15] [16] [17] The Grüneberg ganglion, [18] an olfactory ganglion in rodents, was first described by Hans Grueneberg in 1973.

Career

  • Honorary Research Assistant, University College London, 1933–38
  • Moseley Research Student of Royal Society, 1938–42
  • Captain, Royal Army Medical Corps, 1942–46
  • Reader in Genetics, University College London, 1946–55
  • Honorary Director of the Medical Research Council Experimental Genetics Unit at University College London, 1955–1972
  • Professor of Genetics University College London, 1956–1974
  • Affiliated with the Department of Pathology, Mount Vernon Hospital, Northwood, Middlesex
  • Emeritus Professor University College London, from retirement, 1974

Books

  • 1947. Animal genetics and medicine. Hamish Hamilton, London.
  • 1952. The genetics of the mouse. 2nd ed, revised and enlarged. Nijhoff, The Hague.
  • 1963. The pathology of development: a study of inherited skeletal disorders in animals. Wiley, London.

References

  1. ^ a b Lewis, Dan; Hunt, D. M. (1984). "Hans Grüneberg. 26 May 1907 – 23 October 1982". Biographical Memoirs of Fellows of the Royal Society. 30: 226–247. doi: 10.1098/rsbm.1984.0008. JSTOR  769826. PMID  11616003. S2CID  7536917.
  2. ^ Grüneberg, H.; Wickramaratne, G. A. (1974). "A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch)". Journal of Embryology and Experimental Morphology. 31 (1): 207–222. PMID  4819561.
  3. ^ Grüneberg, H.; Lee, A. J. (1973). "The anatomy and development of brachypodism in the mouse". Journal of Embryology and Experimental Morphology. 30 (1): 119–141. PMID  4729943.
  4. ^ Grüneberg, H. (1971). "Exocrine glands and the Chievitz organ of some mouse mutants". Journal of Embryology and Experimental Morphology. 25 (2): 247–261. PMID  5088022.
  5. ^ Grüneberg, H. (1971). "The glandular aspects of the tabby syndrome in the mouse". Journal of Embryology and Experimental Morphology. 25 (1): 1–19. PMID  5548211.
  6. ^ Grüneberg, H. (1969). "Threshold phenomena versus cell heredity in the manifestation of sex-linked genes in mammals". Journal of Embryology and Experimental Morphology. 22 (2): 145–179. PMID  5361553.
  7. ^ Grüneberg, H. (1966). "More about the tabby mouse and about the Lyon hypothesis". Journal of Embryology and Experimental Morphology. 16 (3): 569–590. PMID  5962700.
  8. ^ Grüneberg, H. (1966). "The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis". Journal of Embryology and Experimental Morphology. 15 (2): 223–244. PMID  5959976.
  9. ^ Grüneberg, H. (1965). "Genes and genotypes affecting the teeth of the mouse". Journal of Embryology and Experimental Morphology. 14 (2): 137–159. PMID  5893447.
  10. ^ Gruneberg, H. (1958). "Genetical studies on the skeleton of the mouse. XXIII. The development of brachyury and anury". Journal of Embryology and Experimental Morphology. 6 (3): 424–443. PMID  13575656.
  11. ^ Gruneberg, H. (1958). "Genetical studies on the skeleton of the mouse. XXII. The development of Danforth's short-tail". Journal of Embryology and Experimental Morphology. 6 (1): 124–148. PMID  13539275.
  12. ^ Grüneberg, H.; Burnett, J. B.; Snell, G. D. (1941). "The Origin of Jerker, a New Gene Mutation of the House Mouse, and Linkage Studies Made with It". Proceedings of the National Academy of Sciences of the United States of America. 27 (12): 562–565. Bibcode: 1941PNAS...27..562G. doi: 10.1073/pnas.27.12.562. PMC  1078382. PMID  16588504.
  13. ^ Grüneberg, H. (1939). "Inherited Macrocytic Anemias in the House Mouse". Genetics. 24 (6): 777–810. doi: 10.1093/genetics/24.6.777. PMC  1209073. PMID  17246952.
  14. ^ medical-dictionary
  15. ^ Grüneberg, H. (1970). "Is there a viral component in the genetic background?". Nature. 225 (5227): 39–41. Bibcode: 1970Natur.225...39G. doi: 10.1038/225039a0. PMID  5410193. S2CID  4269949.
  16. ^ Gruneberg, H. (1956). "A ventral ectodermal ridge of the tail in mouse embryos". Nature. 177 (4513): 787–788. Bibcode: 1956Natur.177..787G. doi: 10.1038/177787b0. PMID  13321960. S2CID  4178438.
  17. ^ Grüneberg, H. (1954). "Variation Within Inbred Strains of Mice". Nature. 173 (4406): 674–676. Bibcode: 1954Natur.173..674G. doi: 10.1038/173674a0. PMID  13165620. S2CID  4257744.
  18. ^ Grüneberg, H. (1973). "A ganglion probably belonging to the N. Terminalis system in the nasal mucosa of the mouse". Zeitschrift für Anatomie und Entwicklungsgeschichte. 140 (1): 39–52. doi: 10.1007/BF00520716. PMID  4749131. S2CID  10216579.

External links

Sources


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