Johanna M. Jansen, Ph.D. | |
---|---|
Other names | Hanneke |
Alma mater | Rijksuniversiteit Groningen, Uppsala University |
Scientific career | |
Thesis | Three Dimensions in Drug Design: Probing the melatonin receptor |
Website | https://www.novartis.com/our-science/postdoc-program/leadership/johanna-hanneke-jansen-phd |
Johanna Maria "Hanneke" Jansen is a computational chemist working at Novartis on multiple drug targets. She previously worked at Astra and at Chiron Corporation. [1]
Jansen received her doctoral degree from the University of Groningen (The Netherlands) in 1995, studying computational medicinal chemistry. Her dissertation topic [2] concerned 3D modeling of the melatonin receptor, including work on synthesizing and separating analytes [3] [4] to probe its chemistry. She completed a postdoctoral fellowship at Uppsala University in 1997. Her work there related to modeling receptor interactions [5] of drug leads to judge their serotonergic or dopaminergic activities.
Much of Jansen's oeuvre uses in silico methods to study receptor biology, drug design, and drug-protein interactions. An early study (2000) while she was employed at Chiron looked at conformations of the anti-cancer treatment Taxol in nonpolar environments. [6]
In a 2012 commentary for Future Medicinal Chemistry, Jansen led a team of distinguished computational chemists in a call to action, namely that standardized data sets be used across the industry, and that sharing program code between groups at different companies and institutions should be mandated. [7]
A 2017 open-access study in PLoS One related some of Novartis' work - spearheaded by Jansen - to study the oncogenic protein RAS through inhibitors that targeted its inactive conformations. [8]
Jansen has served the ACS division on Computers in Chemistry since at least 2007, holding multiple leadership positions. [9] [10] Outside of pharmaceutical work, she is perhaps best known as a co-Founder and Steering Committee member for the Teach-Discover-Treat initiative, [11] which creates challenges for students and young professionals to design drugs against neglected diseases such as malaria or Trypanosoma using computational chemistry shared data sets and screens.
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cite web}}
: CS1 maint: multiple names: authors list (
link)
Johanna M. Jansen, Ph.D. | |
---|---|
Other names | Hanneke |
Alma mater | Rijksuniversiteit Groningen, Uppsala University |
Scientific career | |
Thesis | Three Dimensions in Drug Design: Probing the melatonin receptor |
Website | https://www.novartis.com/our-science/postdoc-program/leadership/johanna-hanneke-jansen-phd |
Johanna Maria "Hanneke" Jansen is a computational chemist working at Novartis on multiple drug targets. She previously worked at Astra and at Chiron Corporation. [1]
Jansen received her doctoral degree from the University of Groningen (The Netherlands) in 1995, studying computational medicinal chemistry. Her dissertation topic [2] concerned 3D modeling of the melatonin receptor, including work on synthesizing and separating analytes [3] [4] to probe its chemistry. She completed a postdoctoral fellowship at Uppsala University in 1997. Her work there related to modeling receptor interactions [5] of drug leads to judge their serotonergic or dopaminergic activities.
Much of Jansen's oeuvre uses in silico methods to study receptor biology, drug design, and drug-protein interactions. An early study (2000) while she was employed at Chiron looked at conformations of the anti-cancer treatment Taxol in nonpolar environments. [6]
In a 2012 commentary for Future Medicinal Chemistry, Jansen led a team of distinguished computational chemists in a call to action, namely that standardized data sets be used across the industry, and that sharing program code between groups at different companies and institutions should be mandated. [7]
A 2017 open-access study in PLoS One related some of Novartis' work - spearheaded by Jansen - to study the oncogenic protein RAS through inhibitors that targeted its inactive conformations. [8]
Jansen has served the ACS division on Computers in Chemistry since at least 2007, holding multiple leadership positions. [9] [10] Outside of pharmaceutical work, she is perhaps best known as a co-Founder and Steering Committee member for the Teach-Discover-Treat initiative, [11] which creates challenges for students and young professionals to design drugs against neglected diseases such as malaria or Trypanosoma using computational chemistry shared data sets and screens.
{{
cite web}}
: CS1 maint: multiple names: authors list (
link)