Halichondria is a genus of
sea sponges belonging to the family
Halichondriidae.[1][2]
These are massive, amorphous sponges with clearly separated inner and outer skeletons consisting of bundles of
spicules arranged in a seemingly random pattern.
This genus of sponges became important through the discovery of
cell division limiting properties of the extract
Halichondrin B, which inhibits cell
mitosis. The drug
Eribulin, a related compound and an inhibitor of
microtubule function, has become an important
chemotherapy treatment for certain types of cancer.[3][4][5][6][7]
Species
The following species are recognised in the genus Halichondria:[1]
^
abcvan Soest, R. (2020). Van Soest RW, Boury-Esnault N, Hooper JN, Rützler K, de Voogd NJ, de Glasby BA, Hajdu E, Pisera AB, Manconi R, Schoenberg C, Janussen D, Tabachnick KR, Klautau M, Picton B, Kelly M, Vacelet J (eds.).
"Halichondria Fleming, 1828". World Porifera database.
World Register of Marine Species. Retrieved 2020-09-14.
^Towle, Murray J.; Salvato, Kathleen A.; Budrow, Jacqueline; Wels, Bruce F.; Kuznetsov, Galina; Aalfs, Kimberley K.; Welsh, Susan; Zheng, Wanjun; Seletsk, Boris M.; Palme, Monica H.; Habgood, Gregory J.; Singer, Lori A.; Dipietro, Lucian V.; Wang, Yuan; Chen, Jack J.; Quincy, David A.; Davis, Ashley; Yoshimatsu, Kentaro; Kishi, Yoshito; Yu, Melvin J.; Littlefield, Bruce A. (2 February 2001).
"In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B". Cancer Research. 61 (3): 1013–1021.
PMID11221827.
^Yu, Melvin J.; Kishi, Yoshito; Littlefield, Bruce A. (2005). "Discovery of E7389, a fully synthetic macrocyclic ketone analogue of halichondrin B". In Newman, David J.; Kingston, David G.I.; Cragg, Gordon M. (eds.). Anticancer agents from natural products. Washington, DC: Taylor & Francis.
ISBN978-0-8493-1863-4.
OCLC57169963.
Halichondria is a genus of
sea sponges belonging to the family
Halichondriidae.[1][2]
These are massive, amorphous sponges with clearly separated inner and outer skeletons consisting of bundles of
spicules arranged in a seemingly random pattern.
This genus of sponges became important through the discovery of
cell division limiting properties of the extract
Halichondrin B, which inhibits cell
mitosis. The drug
Eribulin, a related compound and an inhibitor of
microtubule function, has become an important
chemotherapy treatment for certain types of cancer.[3][4][5][6][7]
Species
The following species are recognised in the genus Halichondria:[1]
^
abcvan Soest, R. (2020). Van Soest RW, Boury-Esnault N, Hooper JN, Rützler K, de Voogd NJ, de Glasby BA, Hajdu E, Pisera AB, Manconi R, Schoenberg C, Janussen D, Tabachnick KR, Klautau M, Picton B, Kelly M, Vacelet J (eds.).
"Halichondria Fleming, 1828". World Porifera database.
World Register of Marine Species. Retrieved 2020-09-14.
^Towle, Murray J.; Salvato, Kathleen A.; Budrow, Jacqueline; Wels, Bruce F.; Kuznetsov, Galina; Aalfs, Kimberley K.; Welsh, Susan; Zheng, Wanjun; Seletsk, Boris M.; Palme, Monica H.; Habgood, Gregory J.; Singer, Lori A.; Dipietro, Lucian V.; Wang, Yuan; Chen, Jack J.; Quincy, David A.; Davis, Ashley; Yoshimatsu, Kentaro; Kishi, Yoshito; Yu, Melvin J.; Littlefield, Bruce A. (2 February 2001).
"In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B". Cancer Research. 61 (3): 1013–1021.
PMID11221827.
^Yu, Melvin J.; Kishi, Yoshito; Littlefield, Bruce A. (2005). "Discovery of E7389, a fully synthetic macrocyclic ketone analogue of halichondrin B". In Newman, David J.; Kingston, David G.I.; Cragg, Gordon M. (eds.). Anticancer agents from natural products. Washington, DC: Taylor & Francis.
ISBN978-0-8493-1863-4.
OCLC57169963.