Hyaluronidase-3 is an
enzyme that in humans is encoded by the HYAL3gene.[5][6]
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade
hyaluronan, one of the major
glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Csoka AB, Scherer SW, Stern R (Nov 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31". Genomics. 60 (3): 356–61.
doi:
10.1006/geno.1999.5876.
PMID10493834.
Junker N, Latini S, Petersen LN, Kristjansen PE (2003). "Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncol. Rep. 10 (3): 609–16.
doi:
10.3892/or.10.3.609 (inactive 31 January 2024).
PMID12684632.{{
cite journal}}: CS1 maint: DOI inactive as of January 2024 (
link)
Hyaluronidase-3 is an
enzyme that in humans is encoded by the HYAL3gene.[5][6]
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade
hyaluronan, one of the major
glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Csoka AB, Scherer SW, Stern R (Nov 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31". Genomics. 60 (3): 356–61.
doi:
10.1006/geno.1999.5876.
PMID10493834.
Junker N, Latini S, Petersen LN, Kristjansen PE (2003). "Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncol. Rep. 10 (3): 609–16.
doi:
10.3892/or.10.3.609 (inactive 31 January 2024).
PMID12684632.{{
cite journal}}: CS1 maint: DOI inactive as of January 2024 (
link)