Arf-GAP domain and FG repeat-containing protein 1 is a
protein that in humans is encoded by the AGFG1gene.[5][6]
Function
The protein encoded by this gene is related to
nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]
Güre AO, Altorki NK, Stockert E, Scanlan MJ, Old LJ, Chen YT (1998). "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res. 58 (5): 1034–41.
PMID9500467.
Kiss A, Li L, Gettemeier T, Venkatesh LK (2003). "Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors". Virology. 314 (2): 591–600.
doi:
10.1016/S0042-6822(03)00531-2.
PMID14554087.
Arf-GAP domain and FG repeat-containing protein 1 is a
protein that in humans is encoded by the AGFG1gene.[5][6]
Function
The protein encoded by this gene is related to
nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]
Güre AO, Altorki NK, Stockert E, Scanlan MJ, Old LJ, Chen YT (1998). "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res. 58 (5): 1034–41.
PMID9500467.
Kiss A, Li L, Gettemeier T, Venkatesh LK (2003). "Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors". Virology. 314 (2): 591–600.
doi:
10.1016/S0042-6822(03)00531-2.
PMID14554087.