HPE may refer to:

Cars

• Lancia Beta HPE, introduced 1975
• Lancia Delta HPE, introduced 1995

Organizations

• Hennessey Performance Engineering, American hypercar manufacturer
• Hewlett Packard Enterprise, American multinational information technology company
• United Alignment of Nationalists (Greek: Ηνωμένη Παράταξις Εθνικοφρόνων), a Greek political alliance
• Êzîdxan Protection Force (Kurdish: Hêza Parastina Êzîdxanê, HPÊ)

Science and technology

• High-pressure electrolysis
• Holoprosencephaly, a cephalic disorder

Other uses

• High Point Enterprise, a US newspaper
• Hope railway station (Wales) (station code), in Flintshire, Wales

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