The HP1 Holin (HP1 Holin) Family ( TC# 1.E.7 ) is a member of the Holin Superfamily II. [1] Proteins in this family are typically found to contain two transmembrane segments (TMSs) and range between 70 and 80 amino acyl residues (aas) in length. A representative list of proteins belonging to the HP1 holin family can be found in the Transporter Classification Database.
The NucE protein ( TC# 1.E.25.2.1) in Serratia marcescens shows homology to phage holin proteins involved in releasing lysozyme to the peptidoglycan of Gram-negative bacteria. The protein contains two characteristic transmembrane segments (TMSs) with a positively charged C-terminus. When the nucC operon carrying the nucEDC genes is placed in the Escherichia coli chromosome, NucE functions as a holin. Additionally, NucE can complement lysis-defective bacteriophage mutants to allow for plaque formation and release of phage. Although NucE can function as a holin it is not involved in the transport of nuclease, an extracellular protein encoded by the nucA gene. [2] [3] [4]
As of 10 March 2016, this article is derived in whole or in part from Transporter Classification Database (TCDB). The copyright holder has licensed the content in a manner that permits reuse under CC BY-SA 3.0 and GFDL. All relevant terms must be followed. The original text was at "1.E.7 The HP1 Holin (HP1 Holin) Family"
The HP1 Holin (HP1 Holin) Family ( TC# 1.E.7 ) is a member of the Holin Superfamily II. [1] Proteins in this family are typically found to contain two transmembrane segments (TMSs) and range between 70 and 80 amino acyl residues (aas) in length. A representative list of proteins belonging to the HP1 holin family can be found in the Transporter Classification Database.
The NucE protein ( TC# 1.E.25.2.1) in Serratia marcescens shows homology to phage holin proteins involved in releasing lysozyme to the peptidoglycan of Gram-negative bacteria. The protein contains two characteristic transmembrane segments (TMSs) with a positively charged C-terminus. When the nucC operon carrying the nucEDC genes is placed in the Escherichia coli chromosome, NucE functions as a holin. Additionally, NucE can complement lysis-defective bacteriophage mutants to allow for plaque formation and release of phage. Although NucE can function as a holin it is not involved in the transport of nuclease, an extracellular protein encoded by the nucA gene. [2] [3] [4]
As of 10 March 2016, this article is derived in whole or in part from Transporter Classification Database (TCDB). The copyright holder has licensed the content in a manner that permits reuse under CC BY-SA 3.0 and GFDL. All relevant terms must be followed. The original text was at "1.E.7 The HP1 Holin (HP1 Holin) Family"