Ubiquitin-conjugating enzyme E2 K is a
protein that in humans is encoded by the UBE2Kgene.[5][6][7]
The protein encoded by this gene belongs to the
ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of
huntingtin. This interaction is not influenced by the length of the huntingtin
polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of
apoptosis.[7]
^Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (Aug 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4.
doi:
10.1016/S0014-5793(01)02689-8.
PMID11513855.
S2CID42977319.
Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4.
doi:
10.1016/S0014-5793(01)02689-8.
PMID11513855.
S2CID42977319.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9.
doi:
10.1038/nbt810.
PMID12665801.
S2CID23783563.
de Pril R, Fischer DF, Roos RA, van Leeuwen FW (2007). "Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases". Mol. Cell. Neurosci. 34 (1): 10–9.
doi:
10.1016/j.mcn.2006.09.006.
PMID17092742.
S2CID9704303.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89.
doi:
10.1038/msb4100134.
PMC1847948.
PMID17353931.
Ubiquitin-conjugating enzyme E2 K is a
protein that in humans is encoded by the UBE2Kgene.[5][6][7]
The protein encoded by this gene belongs to the
ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of
huntingtin. This interaction is not influenced by the length of the huntingtin
polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of
apoptosis.[7]
^Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (Aug 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4.
doi:
10.1016/S0014-5793(01)02689-8.
PMID11513855.
S2CID42977319.
Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4.
doi:
10.1016/S0014-5793(01)02689-8.
PMID11513855.
S2CID42977319.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9.
doi:
10.1038/nbt810.
PMID12665801.
S2CID23783563.
de Pril R, Fischer DF, Roos RA, van Leeuwen FW (2007). "Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases". Mol. Cell. Neurosci. 34 (1): 10–9.
doi:
10.1016/j.mcn.2006.09.006.
PMID17092742.
S2CID9704303.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89.
doi:
10.1038/msb4100134.
PMC1847948.
PMID17353931.