From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a
protein that in humans is encoded by the HECW1
gene .
[5] In human it has 1606
amino acids (179.5 kDa) and
isoelectric point of 5.18.
[6]
References
Further reading
Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A (March 2004).
"NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1" . The Journal of Biological Chemistry . 279 (12): 11327–35.
doi :
10.1074/jbc.M312389200 .
PMID
14684739 .
Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD (January 2011).
"The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity" . PLOS ONE . 6 (1): e14583.
Bibcode :
2011PLoSO...614583C .
doi :
10.1371/journal.pone.0014583 .
PMC
3026782 .
PMID
21283621 .
Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC (January 2014).
"Genome-wide association study of the rate of cognitive decline in Alzheimer's disease" . Alzheimer's & Dementia . 10 (1): 45–52.
doi :
10.1016/j.jalz.2013.01.008 .
PMC
3760995 .
PMID
23535033 .
Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A (June 2008).
"A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner" . Oncogene . 27 (26): 3700–9.
doi :
10.1038/sj.onc.1211032 .
PMID
18223681 .
Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001).
"The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel" . The Journal of Biological Chemistry . 276 (11): 8597–601.
doi :
10.1074/jbc.C000906200 .
PMID
11244092 .
Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A (2011).
"Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice" . Journal of Biomedicine & Biotechnology . 2011 : 1–7.
doi :
10.1155/2011/831092 .
PMC
2952905 .
PMID
20976258 .
Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L (May 2011).
"SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1" . The EMBO Journal . 30 (13): 2675–89.
doi :
10.1038/emboj.2011.155 .
PMC
3155294 .
PMID
21572392 .
Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S (January 2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription". Biochemical and Biophysical Research Communications . 404 (1): 143–7.
doi :
10.1016/j.bbrc.2010.11.082 .
hdl :
2115/44929 .
PMID
21108931 .
S2CID
8665279 .
Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyrén O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL (December 2013).
"A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus" . Nature Genetics . 45 (12): 1487–93.
doi :
10.1038/ng.2796 .
PMC
3840115 .
PMID
24121790 .