Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 is an
enzyme that in humans is encoded by the AGAP1gene.[5]
Function
CENTG2 belongs to an ADP-ribosylation factor GTPase-activating (ARF-GAP) protein family involved in membrane traffic and actin cytoskeleton dynamics (Nie et al., 2002).[supplied by OMIM][5]
HACNS1
HACNS1 is located in an intron of the gene CENTG2 (also known as
Human Accelerated Region 2). HACNS1 is hypothesized to be a
gene enhancer "that may have contributed to the evolution of the uniquely opposable
humanthumb, and possibly also modifications in the
ankle or
foot that allow humans to
walk on two legs". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human
genome, HACNS1 has undergone the most change during the
evolution of humans following the split with the ancestors of
chimpanzees.[6]
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54.
doi:
10.1007/s00335-005-0075-2.
PMID16341674.
S2CID69278.
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 is an
enzyme that in humans is encoded by the AGAP1gene.[5]
Function
CENTG2 belongs to an ADP-ribosylation factor GTPase-activating (ARF-GAP) protein family involved in membrane traffic and actin cytoskeleton dynamics (Nie et al., 2002).[supplied by OMIM][5]
HACNS1
HACNS1 is located in an intron of the gene CENTG2 (also known as
Human Accelerated Region 2). HACNS1 is hypothesized to be a
gene enhancer "that may have contributed to the evolution of the uniquely opposable
humanthumb, and possibly also modifications in the
ankle or
foot that allow humans to
walk on two legs". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human
genome, HACNS1 has undergone the most change during the
evolution of humans following the split with the ancestors of
chimpanzees.[6]
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54.
doi:
10.1007/s00335-005-0075-2.
PMID16341674.
S2CID69278.